Prevent Type 2 Diabetes: Insights from Family History and Genomics - February 9, 2015

Genomics|Features|Diabetes

Diabetes

Prevent Type 2 Diabetes: Insights from Family History and Genomics - February 9, 2015

CDC information: Prevent or delay type 2 diabetes by learning your risk factors, eating right, becoming more physically active, losing a modest amount of weight, and managing stress. You can make a healthy change today

Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes.
Johansen Taber KA, et al. Appl Clin Genet. 2015 Jan 7;8:1-8.

Rare and common genetic events in type 2 diabetes: What should biologists know?
Bonnefond A, et al. Cell Metab. 2015 Jan 27. pii:

Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.
Berná G, et al. Nutrients. 2014 Nov 21;6(11):5338-69

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Wessel J. et al. Nat Commun. 2015 Jan 29;6:5897

Type 2 Diabetes: Family History and Genetics - November 13, 2014

CDC feature: Will diabetes be part of your story? Know your risk for diabetes and see if it could be a part of your story

National Diabetes Education Program Video:  Preventing Type 2 Diabetes: Maintaining a healthy weight. Losing weight wasn't easy for Latecia, but after seeing her mom live with diabetes, she knew she needed to make changes in her life to prevent the disease

Does diabetes run in your family? Take steps towards better health!

Recent Insights

Susceptibility to type 2 diabetes mellitus—from genes to prevention. 
Marie-France Hivert et al. Nature Reviews Endocrinology 2014;10:198-205

Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.
Basile KJ, et al. Curr Diab Rep. 2014 Nov;14(11):550.

Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes.
Vaag A, et al. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108

Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus.
Banerjee M, et al. World J Diabetes. 2014 Aug 15;5(4):493-504.

Metformin pharmacogenomics: current status and future directions.
Pawlyk AC, et al. Diabetes. 2014 Aug;63(8):2590-9.

Diabetes & Pregnancy: Role of Genetics and Family History - November 6, 2014

CDC information: November is Diabetes Awareness Month. How much do you know about diabetes during pregnancy? Check your knowledge

From the National Diabetes Education Program: Family Health History and Diabetes- If you are a woman who had gestational diabetes during pregnancy, you are at increased risk for developing diabetes, and the child of that pregnancy is at increased risk for obesity and type 2 diabetes

From Medline & NLM Reference: You are at greater risk for gestational diabetes if you have a family history of diabetes

Did you know? 264 genes have been reported in relation to risk and outcomes of gestational diabetes, including 2 genomewide association studies. To find out more, visit the HuGE Navigator

Recent Insights

Obesity and diabetes: from genetics to epigenetics.
Burgio E, et al. Mol Biol Rep. 2014 Sep 25

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.
Quilter CR, et al. FASEB J. 2014 Nov;28(11):4868-79

Genetic counseling for diabetes mellitus.
Stein SA, et al. Curr Genet Med Rep. 2014 Jun 1;2(2):56-67.

Diabetes Prevention: Family History and Genetics - September 11, 2014

Recommendation from the Task Force on Community Preventive Services (2014) Diabetes Prevention and Control: Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among People at Increased Risk

CDC information: More than 29 million Americans have diabetes; 1 in 4 doesn't know

If you have a mom, dad, brother or sister with type 2 diabetes you have a greater chance of getting the disease, the National Diabetes Education Program

CDC information: Prediabetes: Am I at risk?

Did you know? More than 3400 genes have been reported with risk of type 2 diabetes and its outcomes, including more than 160 genomewide association studies. To find out more, visit theHuGE Navigator

The fight against type 2 diabetes: The promise of genomics, Sandra Adamson Fryhofer, Medscape podcast, July 11, 2014

Check out genetic disorders and tests associated with diabetes at the NIH Genetic Testing Registry

Diabetes Complications: Role of Genomics - May 8, 2014

The global diabetes epidemic  "A perfect storm of commerce, lifestyle and genetics", by Kasia Lipska, New York Times, Apr 25

CDC information on diabetes complications: If you have diabetes, it's important to take care of your feet and the rest of your body

The genetics of vascular complications in diabetes mellitus
Dan Farbstein, et al. Cardiol Clin. 2010 Aug;28(3):477-96

Mechanisms of diabetic complications
Forbes JM. Physiol Rev (2013)

Metabolic memory and chronic diabetes complications: Potential role for epigenetic mechanisms 
Robert V. Inti et al. Current Diabetes Rep (2013)

Did you know? More than 3300 genes have been reported in relation to risk of type 2 diabetes and its complications? For additional information, visit the HuGE Navigator

Did you know? 19 genomewide association studies have reported on genetic risk in relation to diabetes complications? Find out more from the HuGE Navigator