Recent findings on genetics of systemic autoimmune... [Curr Opin Immunol. 2010] - PubMed result

Curr Opin Immunol. 2010 Oct 6. [Epub ahead of print]
Recent findings on genetics of systemic autoimmune diseases.

Delgado-Vega A, Sánchez E, Löfgren S, Castillejo-López C, Alarcón-Riquelme ME.

Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarsjölds väg 20, 751 85 Uppsala, Sweden.

Abstract

Association studies of over 1 million SNPs capturing most of the human genome common variation became possible thanks to the information provided by the HapMap International project and the development of high-throughput genotyping technologies at accessible prices. Genome-wide scans analyzing thousands of individuals have now identified most if not all of the major genes involved in susceptibility for several systemic autoimmune diseases. In particular, results for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) are reviewed here. While most genes are shared between diseases, few seem to be unique reflecting that we still are long before knowing all genes, their interactions with other genes and the environment and their impact on biological functions.
Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID: 20933377 [PubMed - as supplied by publisher]
Recent findings on genetics of systemic autoimmune... [Curr Opin Immunol. 2010] - PubMed result

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