Enterovirus 75 Encephalitis in Children - Southern India | CDC EID

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Volume 16, Number 11–November 2010
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Enterovirus 75 Encephalitis in Children, Southern India

Penny Lewthwaite, Comments to Author David Perera, Mong How Ooi, Anna Last, Ravi Kumar, Anita Desai, Ashia Begum, Vasanthapuram Ravi, M. Veera Shankar, Phaik Hooi Tio, Mary Jane Cardosa, and Tom Solomon
Author affiliations: University of Liverpool, Liverpool, UK (P. Lewthwaite, M.H. Ooi, A. Last, T. Solomon); Universiti Malaysia Sarawak, Sarawak, Malaysia (D. Perera, M.H. Ooi, P.H. Tio, M.J. Cardosa); Sibu Hospital, Sibu, Sarawak (M.H. Ooi); Vijayanagar Institute of Medical Sciences, Karnataka, India (R. Kumar, A. Begum, M. Veera Shankar); and National Institute of Mental Health and Neurological Sciences, Bangalore, India (R. Kumar, A. Desai, V. Ravi)

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Abstract
Recent outbreaks of enterovirus in Southeast Asia emphasize difficulties in diagnosis of this infection. To address this issue, we report 5 (4.7%) children infected with enterovirus 75 among 106 children with acute encephalitis syndrome during 2005–2007 in southern India. Throat swab specimens may be useful for diagnosis of enterovirus 75 infection.

Sequences of enterovirus 75 (EV75) were first identified in cerebrospinal fluid (CSF), stool samples, and throat samples obtained during 1974–2000 in Ethiopia, Oman, Bangladesh, and the United States; the new enterovirus serotype was proposed in 2004 (1). Manifestations include upper respiratory tract infections and acute flaccid paralysis. In 2005–2006, EV75 was associated with aseptic meningitis in Spain (2,3). Enteroviruses have long been associated with encephalitis, but recent outbreaks of EV71 in Southeast Asia have highlighted the diagnostic difficulties that may be encountered (4–6). We report EV75 associated with encephalitis in India.

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Enterovirus 75 Encephalitis in Children | CDC EID

Suggested Citation for this Article

Lewthwaite P, Perera D, Ooi MH, Last A, Kumar R, Desai A, et al. Enterovirus 75 encephalitis in children, southern India. Emerg Infect Dis [serial on the Internet]. 2010 Nov [date cited]. http://www.cdc.gov/EID/content/16/11/1780.htm

DOI: 10.3201/eid1611.100672