Host Genetics and HIV-1: The Final Phase?

PLoS Pathog. 2010 Oct 14;6(10):e1001033.
Host Genetics and HIV-1: The Final Phase?

Fellay J, Shianna KV, Telenti A, Goldstein DB.

Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America.

Abstract

This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.

PMID: 20976252 [PubMed - in process]PMCID: PMC2954832
Free PMC Article
Host Genetics and HIV-1: The Final Phase?