domingo, 31 de octubre de 2010

Host Genetics and HIV-1: The Final Phase?

PLoS Pathog. 2010 Oct 14;6(10):e1001033.
Host Genetics and HIV-1: The Final Phase?

Fellay J, Shianna KV, Telenti A, Goldstein DB.

Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America.


This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.

PMID: 20976252 [PubMed - in process]PMCID: PMC2954832
Free PMC Article
Host Genetics and HIV-1: The Final Phase?

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