domingo, 31 de octubre de 2010
Cephalalgia. 2010 Nov;30(11):1306-28. Epub 2010 May 4.
Sex hormone receptor gene polymorphisms and migraine: a systematic review and meta-analysis.
Schürks M, Rist PM, Kurth T.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA.
BACKGROUND: Data on the association between sex hormone receptor polymorphisms and migraine are conflicting.
METHODS: We performed a systematic review and meta-analysis on this topic searching for studies published until August 2009. For each study, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.
RESULTS AND CONCLUSION: Among the seven genes targeted, four variants were investigated in multiple studies. Effect estimates from an additive model suggest that the ESR-1 594 G>A (pooled OR 1.37; 95% CI 1.02-1.83) and ESR-1 325 C>G (pooled OR 1.16; 95% CI 1.03-1.32) variants are associated with any migraine. This pattern does not differ between migraine with and without aura. In contrast, the ESR-1 Pvu II C>T and PGR PROGINS insert polymorphism do not appear to be associated with migraine. Results were driven by studies among Caucasians and may differ in other ethnic groups.
PMID: 20959426 [PubMed - in process]
Sex hormone receptor gene polymorphisms and migrai... [Cephalalgia. 2010] - PubMed result