5-HTTLPR polymorphism in the serotonin transporter... [Cephalalgia. 2010] - PubMed result

Cephalalgia. 2010 Nov;30(11):1296-305. Epub 2010 Mar 26.
5-HTTLPR polymorphism in the serotonin transporter gene and migraine: a systematic review and meta-analysis.

Schürks M, Rist PM, Kurth T.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA.
mschuerks@rics.bwh.harvard.edu

Abstract

BACKGROUND AND METHODS: Data on the association between the SLC6A4 5-HTTLPR polymorphism and migraine are conflicting. We performed a systematic review and meta-analysis among studies published up to September 2009. For each study with genotype information, we calculated odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.

RESULTS: Among the ten studies identified there was no overall association between the polymorphism and any migraine for Europeans or Asians. However, European women carrying the S allele had an increased risk for any migraine (dominant model: pooled OR=2.02; 95% CI 1.24-3.28). Results among Europeans further suggested an increased risk for migraine with aura among carriers of the S/S genotype (recessive model: pooled OR=1.41; 95% CI 0.83-2.40).

CONCLUSIONS: While our results indicate no overall association between the SLC6A4 5-HTTLPR polymorphism and migraine among Europeans and Asians, gender and migraine aura status may have modifying roles among Europeans.

PMID: 20959425 [PubMed - in process]

5-HTTLPR polymorphism in the serotonin transporter... [Cephalalgia. 2010] - PubMed result