Proteomic investigation of epigenetics in neuropsy... [J Proteome Res. 2010] - PubMed result

J Proteome Res. 2010 Aug 25. [Epub ahead of print]

Proteomic investigation of epigenetics in neuropsychiatric disorders: A missing link between genetics and behavior?
Plazas-Mayorca MD, Vrana KE.

Abstract
Neuropsychiatric disorders affect a large segment of the human population and result in large costs to society. The majority of such disorders have unknown underlying causes. Recent evidence suggests an important role for epigenetic regulation in the emergence of neuropsychiatric disease. Epigenetics may provide a link between genetic and environmental factors and behavior. Epigenetic signaling involves changes on the structure of chromatin; such changes are often triggered and maintained by the post-translational modification of chromatin proteins and/or DNA. Recent proteomic technologies have enabled the study of epigenetic mechanisms in a high-throughput manner. This review will provide an overview of the major epigenetic pathways and modern techniques for their study, before focusing on experimental evidence supporting a strong role for epigenetics in selected psychiatric disorders such as depression, schizophrenia and drug addiction. These results highlight a great need for the inclusion of the proteomic characterization of epigenetic mechanisms in the study of gene/disease associations in psychiatric disorders.

PMID: 20735116 [PubMed - as supplied by publisher]

open here please, or see below:
Proteomic investigation of epigenetics in neuropsy... [J Proteome Res. 2010] - PubMed result

full-text pdf file:
http://pubs.acs.org/doi/pdf/10.1021/pr100463y