Newcastle To Coordinate An International Research Network To Research The Role Of Genetic Variation In Drug Induced Liver Injury

Newcastle To Coordinate An International Research Network To Research The Role Of Genetic Variation In Drug Induced Liver Injury
Main Category: Liver Disease / Hepatitis
Also Included In: Immune System / Vaccines; Genetics; Pharma Industry / Biotech Industry
Article Date: 13 Sep 2010 - 1:00 PDT


The International Serious Adverse Events Consortium (SAEC) has announced that it will collaborate with Newcastle University to research the genetics of drug induced liver injury. The SAEC is a novel, non-profit international research consortium, formed by the global pharmaceutical industry and the Wellcome Trust, to better understand the role genetics plays in drug safety. Newcastle University is one of the UK's top research universities and has an impressive history of pioneering education and scientific research. The collaboration will be directed from the Institute of Cellular Medicine at the university's Medical School.

The International Drug Induced Liver Injury Consortium (IDILIC) will be co-directed by Professor Ann Daly, Professor of Pharmacogenetics at Newcastle University and Dr. Guru Aithal, Deputy Director of the Digestive Diseases Center at Nottingham University. IDILIC will recruit patients with drug induced serious liver injury reactions, through a collaborative network comprised of 20+ leading research centers from around the world. This collaboration will further the SAEC and Newcastle University's ground breaking research into the genetics of "drug induced liver injury," through a focus on specific causal drugs and populations groups that experience these adverse drug reactions.

"Our genetic research to date points to a strong role of the immune system in these adverse responses," said Arthur L. Holden, Chairman of the SAEC. "To better understand the full genetic effects contributing to these diseases, we need to develop larger and more diverse collections of subjects, in conjunction with international researchers who share our strong interest and have experience with DILI reactions. We are thrilled Newcastle University and Professor Ann Daly share our commitment to such large scale international research collaboration. I can think of no better setting for the IDILIC coordinating center than at Newcastle University. "

Professor Ann Daly said, "This is a great opportunity for the Newcastle and Nottingham teams together with colleagues at the University of Liverpool to continue our productive relationship with the SAEC while forging new links with researchers in Europe, Asia and Australia. International cooperation is vital to enable us to understand these relatively rare but very serious adverse reactions to certain prescription medicines. Our aim is to develop simple genetic tests so that treatment can be personalized and those at risk of these liver reactions prescribed other medicines instead."

Source:
Arthur L. Holden
Edelman Public Relations
Newcastle To Coordinate An International Research Network To Research The Role Of Genetic Variation In Drug Induced Liver Injury