JAMA -- Genome-wide Association Study of Genetic Loci and Alzheimer Disease, August 25, 2010, Brown et al. 304 (8): 858

Genome-wide Association Study of Genetic Loci and Alzheimer Disease

To the Editor: The multistage genome-wide association study (GWAS) analysis of genetic loci associated with Alzheimer disease (AD) conducted by Dr Seshadri and colleagues1 presented evidence for association of 2 novel genetic loci with AD as well as confirmation for 2 previously reported associations (CLU and PICALM). rs744373 is located on chromosome 2, in a region that to our knowledge has not previously been associated with late-onset Alzheimer disease; there are no linkage entries for Chr 2 in http://www.alzgene.org or http://alzres.com.

The one published exception is a study2 that stratified the National Institute of Mental Health Alzheimer Disease Genetics Initiative data set by autopsy status. Linkage analysis limited to autopsy-only sibling pairs identified several unique linkage regions throughout the genome, including one on chromosome 2, centered at 110 cM (half-height range, 90-140 cM), that encompasses rs744373. This correlation between studies provides independent verification for the study by . . . [Full Text of this Article]

Abraham M. Brown, PhD
abraham_brown@nymc.edu
Department of Cell Biology
New York Medical College
Valhalla



Stephen J. Finch, PhD
Department of Applied Mathematics and Statistics
Stony Brook University
Stony Brook, New York



Derek Gordon, PhD
Department of Genetics
Rutgers, The State University of New Jersey
Piscataway

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
Sudha Seshadri, Annette L. Fitzpatrick, M. Arfan Ikram, Anita L. DeStefano, Vilmundur Gudnason, Merce Boada, Joshua C. Bis, Albert V. Smith, Minerva M. Carrasquillo, Jean Charles Lambert, Denise Harold, Elisabeth M. C. Schrijvers, Reposo Ramirez-Lorca, Stephanie Debette, W. T. Longstreth, Jr, A. Cecile J. W. Janssens, V. Shane Pankratz, Jean François Dartigues, Paul Hollingworth, Thor Aspelund, Isabel Hernandez, Alexa Beiser, Lewis H. Kuller, Peter J. Koudstaal, Dennis W. Dickson, Christophe Tzourio, Richard Abraham, Carmen Antunez, Yangchun Du, Jerome I. Rotter, Yurii S. Aulchenko, Tamara B. Harris, Ronald C. Petersen, Claudine Berr, Michael J. Owen, Jesus Lopez-Arrieta, Badri N. Vardarajan, James T. Becker, Fernando Rivadeneira, Michael A. Nalls, Neill R. Graff-Radford, Dominique Campion, Sanford Auerbach, Kenneth Rice, Albert Hofman, Palmi V. Jonsson, Helena Schmidt, Mark Lathrop, Thomas H. Mosley, Rhoda Au, Bruce M. Psaty, Andre G. Uitterlinden, Lindsay A. Farrer, Thomas Lumley, Agustin Ruiz, Julie Williams, Philippe Amouyel, Steve G. Younkin, Philip A. Wolf, Lenore J. Launer, Oscar L. Lopez, Cornelia M. van Duijn, Monique M. B. Breteler, and for the CHARGE, GERAD1, and EADI1 Consortia
JAMA. 2010;303(18):1832-1840.
ABSTRACT | FULL TEXT

RELATED LETTER
Genome-wide Association Study of Genetic Loci and Alzheimer Disease—Reply
Sudha Seshadri, Annette L. Fitzpatrick, M. Arfan Ikram, and For the CHARGE, GERAD1, and EADI1 Consortia
JAMA. 2010;304(8):858.
EXTRACT | FULL TEXT


JAMA -- Genome-wide Association Study of Genetic Loci and Alzheimer Disease, August 25, 2010, Brown et al. 304 (8): 858