From genes to proteins in mendelian Parkinson's di... [Anat Rec (Hoboken). 2009] - PubMed result

Anat Rec (Hoboken). 2009 Dec;292(12):1893-901.

From genes to proteins in mendelian Parkinson's disease: an overview.
Pirkevi C, Lesage S, Brice A, Nazli Başak A.

Boğaziçi University, Molecular Biology and Genetics Department, Neurodegeneration Research Laboratory, Istanbul, Turkey.

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. A progressive movement disorder typified by the production of bradykinesia, tremor, rigidity, and impairment of postural reflexes, PD is characterized by a depletion of dopamine in the striatum. For the last decade, several Mendelian forms of PD have been identified. Mutations in these genes potentially lead to autosomal dominant (alpha-synuclein and LRRK2), or autosomal recessive PD (Parkin, PINK1, DJ1, and ATP13A2). This article will spotlight these six distinct genes unambiguously associated with Mendelian PD and the function of their encoded proteins. Anat Rec, 292:1893-1901, 2009. (c) 2009 Wiley-Liss, Inc.

PMID: 19943343 [PubMed - in process]

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From genes to proteins in mendelian Parkinson's di... [Anat Rec (Hoboken). 2009] - PubMed result