Advances in genetics: widening our understanding of prostate cancer. - PubMed - NCBI

Advances in genetics: widening our understanding of prostate cancer. - PubMed - NCBI

F1000Res. 2016 Jun 27;5. pii: F1000 Faculty Rev-1512. doi: 10.12688/f1000research.8019.1. eCollection 2016.

Advances in genetics: widening our understanding of prostate cancer.

Pine AC1, Fioretti FF2, Brooke GN3, Bevan CL2.

Author information

Abstract

Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate cancer through the application of whole-exome sequencing, and this review summarises recent advances in this field and discusses how exome sequencing could be used clinically to promote personalised medicine for prostate cancer patients.

KEYWORDS:

Androgen; Cancer progression; DNA damage repair; Metastasis; Personalised Medicine; Prostate Cancer; Transcriptome; WES; Whole Exome Sequencing

PMID:

 

27408704

 

PMCID:

 

PMC4926757

 

DOI:

 

10.12688/f1000research.8019.1

[PubMed] 

Free PMC Article