Bioinformatics. 2018 Dec 15;34(24):4315-4317. doi: 10.1093/bioinformatics/bty531.
Database of evidence for precision oncology portal.
Sun SQ1,2, Mashl RJ1,2, Sengupta S1,2, Scott AD1,2, Wang W1,2, Batra P2, Wang LB1,2, Wyczalkowski MA1,2, Ding L1,2,3,4.
Abstract
SUMMARY:
A database of curated genomic variants with clinically supported drug therapies and other oncological annotations is described. The accompanying web portal provides a search engine with two modes: one that allows users to query gene, cancer type, variant type or position for druggable mutations, and another to search for and to visualize, on three-dimensional protein structures, putative druggable sites that cluster with known druggable mutations.
AVAILABILITY AND IMPLEMENTATION:
http://dinglab.wustl.edu/depo.
- PMID:
- 30535306
- PMCID:
- PMC6289129
- [Available on 2019-12-15]
- DOI:
- 10.1093/bioinformatics/bty531
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