CIENCIASMEDICASNEWS: How Does Whole Genome Bisulfite Sequencing Work?

lunes, 19 de noviembre de 2018

How Does Whole Genome Bisulfite Sequencing Work?

	November 19, 2018
	Genomics
	The latest genomics news from AZoNetwork

What is Functional Genomics?

Launched in 1990, the Human Genome Project revolutionized biology, enabling the human genome sequence to be mapped. It was a prime example of ‘big science’ – the large scale, cross-disciplinary approach. The availability of this ground-breaking data has enabled further research into molecular processes and interactions that occur in cells on a genome-wide level.

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How Does Whole Genome Bisulfite Sequencing Work?

Recent advances in sequencing techniques have allowed whole genome sequencing to become more common and quicker. Whole genome bisulfite sequencing (WGBS) is one such next generation sequencing technique that allows users to analyze DNA methylation at single base resolution.

	Using genome editing to prevent sudden cardiac death Each year, at least 3 million people worldwide die of sudden cardiac death. In the U.S., this number reaches up to 450,000 people. Although sudden cardiac death is more common in older adults, younger people also are significantly affected. In the 1 to 40 age group, up to 9 per 100,000 people are affected each year.

	Top researchers call for unified standards in 3D genome and epigenetic data Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease.

	Growth of genomic databases hinders efforts to identify bacteria There are many ways to slice and dice genomic data to identify a species of bacteria, or at least find its close relatives. But fast techniques to sequence genomes have flooded the public databases and in a biased fashion, containing lots of genomic data about some species and not enough about others, according to a Rice University computer scientist.

	CRISPR genome editing has foreseeable implications for plastic and reconstructive surgery The CRISPR genome editing technique promises to be a "transformative leap" in genetic engineering and therapy, affecting almost every area of medicine.

	Applications of Whole Genome Bisulfite Sequencing (WGBS) DNA methylation is an epigenetic mechanism to regulate gene expression and involves adding a methyl group to a cytosine base. Abnormal methylation patterns have been associated with several conditions and diseases, such as cancer. Since the development of WGBS, it has been applied to study epigenetic reprogramming, epigenetic signatures, and others.