Inherited Cancer in the Age of Next-Generation Sequencing. - PubMed - NCBI

Inherited Cancer in the Age of Next-Generation Sequencing. - PubMed - NCBI

Biol Res Nurs. 2018 Jan 1:1099800417750746. doi: 10.1177/1099800417750746. [Epub ahead of print]

Inherited Cancer in the Age of Next-Generation Sequencing.

Price KS1, Svenson A1, King E2, Ready K1, Lazarin GA1.

Author information

Abstract

Next-generation sequencing (NGS) technology has led to the ability to test for multiple cancer susceptibility genes simultaneously without significantly increasing cost or turnaround time. With growing usage of multigene testing for inherited cancer, ongoing education for nurses and other health-care providers about hereditary cancer screening is imperative to ensure appropriate testing candidate identification, test selection, and posttest management. The purpose of this review article is to (1) provide an overview of how NGS works to detect germline mutations, (2) summarize the benefits and limitations of multigene panel testing, (3) describe risk categories of cancer susceptibility genes, and (4) highlight the counseling considerations for patients pursuing multigene testing.

KEYWORDS:

hereditary cancer testing; inherited cancer; multigene panel; next-generation sequencing

PMID:

 

29325452

 

DOI:

 

10.1177/1099800417750746