lunes, 7 de agosto de 2017

Genetic variants in gastric cancer: Risks and clinical implications. - PubMed - NCBI

2017 Jul 20;103(1):101-111. doi: 10.1016/j.yexmp.2017.07.004. [Epub ahead of print]

Genetic variants in gastric cancer: Risks and clinical implications.

Gigek CO1, Calcagno DQ2, Rasmussen LT3, Santos LC4, Leal MF5, Wisnieski F4, Burbano RR6, Lourenço LG7, Lopes-Filho GJ7, Smith MAC4.

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Abstract

Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC.