viernes, 4 de agosto de 2017

BMC Cell Biology | Home page

BMC Cell Biology | Home page

Biomed Central

BMC Cell Biology


Connexin26 mutations and KID syndrome

This micrograph shows a cell with a D50Y mutation in connexin26. Cx26 protein (red) and golgin-97 (green) colocalize more frequently than in wildtype cells. D50Y and I30N mutations result in the formation of aberrant hemichannels that might elevate intracellular calcium levels, which may contribute to the hyperproliferative epidermal phenotypes of KID syndrome.
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