domingo, 9 de agosto de 2015

Toward understanding and exploiting tumor heterogeneity : Nature Medicine : Nature Publishing Group

Figure 2: The clonality of tumor evolution.

In tumor evolution, driver alterations may result in the formation of the initial tumor clone. As further driver alterations occur, these clones then branch off to form subclones. Founder mutations that occur in the original tumor clone…

Toward understanding and exploiting tumor heterogeneity

Nature Medicine

21,

846–853

(2015)

doi:10.1038/nm.3915

Received: 01 July 2015
Accepted: 01 July 2015
Published online: 06 August 2015

Abstract

The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here.

View full text