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Encephalitis Surveillance through the Emerging Infections Program, 1997–2010 - Volume 21, Number 9—September 2015 - Emerging Infectious Disease journal - CDC

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Encephalitis Surveillance through the Emerging Infections Program, 1997–2010 - Volume 21, Number 9—September 2015 - Emerging Infectious Disease journal - CDC





Volume 21, Number 9—September 2015
THEME ISSUE
Emerging Infections Program

CME ACTIVITY - Emerging Infections Program

Encephalitis Surveillance through the Emerging Infections Program, 1997–2010

Karen C. BlochComments to Author  and Carol A. Glaser
Author affiliations: Vanderbilt University, Nashville, Tennessee, USA (K.C. Bloch)Kaiser Permanente, Oakland, California, USA (C.A. Glaser)

Abstract

Encephalitis is a devastating illness that commonly causes neurologic disability and has a case fatality rate >5% in the United States. An etiologic agent is identified in <50% of cases, making diagnosis challenging. The Centers for Disease Control and Prevention Emerging Infections Program (EIP) Encephalitis Project established syndromic surveillance for encephalitis in New York, California, and Tennessee, with the primary goal of increased identification of causative agents and secondary goals of improvements in treatment and outcome. The project represents the largest cohort of patients with encephalitis studied to date and has influenced case definition and diagnostic evaluation of this condition. Results of this project have provided insight into well-established causal pathogens and identified newer causes of infectious and autoimmune encephalitis. The recognition of a possible relationship between enterovirus D68 and acute flaccid paralysis with myelitis underscores the need for ongoing vigilance for emerging causes of neurologic disease.
Encephalitis is a potentially devastating illness: the related case-fatality rate in the United States is >5% (1), and substantial neurologic disability is common among survivors. Historically, this syndromic illness has been difficult to diagnose: an etiologic agent was identified in <50% of encephalitis cases in the United States diagnosed during 1987–1998 (2). A major barrier to diagnosis during that period was the lack of sensitive, noninvasive laboratory techniques to identify central nervous system pathogens. However, by the early 1990s, PCR was proven to be comparable to brain biopsy for the diagnosis of herpes simplex virus (HSV) encephalitis, without the need for an invasive surgical procedure (3). There was optimism that application of PCR could also improve microbiologic diagnoses of encephalitis infections caused by other pathogens and, by extension, the outcome of the illnesses. The Emerging Infections Program (EIP), which is funded by the Centers for Disease Control and Prevention, initiated the Encephalitis Project, a syndromic surveillance program for encephalitis in existing EIP sites beginning in New York in 1997, California in 1998, and Tennessee in 2000, and all ending by 2010.

Dr. Bloch is an Associate Professor in Medicine (Infectious Diseases) and Health Policy at Vanderbilt University in Nashville. She served as the principal investigator for the Tennessee Unexplained Encephalitis Surveillance Project. Her research interests focus on the study of encephalitis and arthropod-borne infections.
Dr. Glaser is a pediatric infectious disease physician at Kaiser Permanente in Oakland, California who served as the principal investigator for the California Encephalitis Project. Her primary research interests are zoonotic illness and neurologic disease.

Acknowledgment

Support for the EIP Encephalitis Project was provided by a grant from the Centers for Disease Control and Prevention Emerging Infections Program to the California Department of Health (U50/CCU915546-09) and to the Tennessee Department of Health (U50/CCU416123-09).

References

  1. Vora NMHolman RCMehal JMSteiner CABlanton JSejvar JBurden of encephalitis-associated hospitalizations in the United States, 1998–2010. Neurology2014;82:44351 . DOIPubMed
  2. Khetsuriani NHolman RCAnderson LJBurden of encephalitis-associated hospitalizations in the United States, 1988–1997. Clin Infect Dis.2002;35:17582 . DOIPubMed
  3. Lakeman FDWhitley RJDiagnosis of herpes simplex encephalitis: application of polymerase chain reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. J Infect Dis.1995;171:85763 . DOIPubMed
  4. Venkatesan ATunkel ARBloch KCLauring ASSejvar JBitnun AInternational Encephalitis Consortium. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the International Encephalitis Consortium. Clin Infect Dis2013;57:111428DOIPubMed
  5. DuBray KAnglemyer ALaBeaud ADFlori HBloch KJoaquin KSEpidemiology, outcomes and predictors of recovery in childhood encephalitis: a hospital-based study. Pediatr Infect Dis J2013;32:83944 .PubMed
  6. Campbell WPHuang CSequence comparisons of medium RNA segment among 15 California serogroup viruses. Virus Res1999;61:13744.DOIPubMed
  7. Huang CCampbell WGrady LKirouac ILaForce FMDiagnosis of Jamestown Canyon encephalitis by polymerase chain reaction. Clin Infect Dis.1999;28:12947DOIPubMed
  8. Huang CMorse DSlater BAnand MTobin ESmith PMultiple-year experience in the diagnosis of viral central nervous system infections with a panel of polymerase chain reaction assays for detection of 11 viruses. Clin Infect Dis2004;39:6305DOIPubMed
  9. Bloch KCGlaser CDiagnostic approaches for patients with suspected encephalitis. Curr Infect Dis Rep2007;9:31522DOIPubMed
  10. Hicar MDEdwards KBloch KPowassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. Pediatr Infect Dis J.2011;30:868DOIPubMed
  11. Tunkel ARGlaser CABloch KCSejvar JJMarra CMRoos KLInfectious Diseases Society of AmericaThe management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis2008;47:30327DOIPubMed
  12. Glaser CAGilliam SSchnurr DForghani BHonarmand SKhetsuriani NCalifornia Encephalitis ProjectIn search of encephalitis etiologies: diagnostic challenges in the California Encephalitis Project, 1998–2000. Clin Infect Dis2003;36:73142DOIPubMed
  13. Christie LJHonarmand STalkington DFGavali SSPreas CPan CYPediatric encephalitis: what is the role of Mycoplasma pneumoniae? Pediatrics.2007;120:30513DOIPubMed
  14. Glaser CAHonarmand SAnderson LJSchnurr DPForghani BCossen CKBeyond viruses: clinical profiles and etiologies associated with encephalitis. Clin Infect Dis2006;43:156577DOIPubMed
  15. Glaser CAGilliam SHonarmand STureen JHLowenstein DHAnderson LJRefractory status epilepticus in suspect encephalitis. Neurocrit Care.2008;9:7482DOIPubMed
  16. Singh RKJoshi SMPotter DMLeber SMCarlson MDShellhaas RACognitive outcomes in febrile infection-related epilepsy syndrome treated with the ketogenic diet. Pediatrics2014;134:e14315DOIPubMed
  17. Weinberg ABloch KCLi STang YWPalmer MTyler KLDual infections of the central nervous system with Epstein-Barr virus. J Infect Dis.2005;191:2347DOIPubMed
  18. Yao KHonarmand SEspinosa AAkhyani NGlaser CJacobson SDetection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis. Ann Neurol2009;65:25767DOIPubMed
  19. Gable MSSheriff HDalmau JTilley DHGlaser CAThe frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis2012;54:899904DOIPubMed
  20. To TMSoldatos ASheriff HSchmid DSEspinosa NCosentino GInsights into pediatric herpes simplex encephalitis from a cohort of 21 children from the California Encephalitis Project, 1998–2011. Pediatr Infect Dis J2014;33:12878DOIPubMed
  21. Fowlkes ALHonarmand SGlaser CYagi SSchnurr DOberste MSEnterovirus-associated encephalitis in the California encephalitis project, 1998–2005. J Infect Dis2008;198:168591DOIPubMed
  22. Christie LJLoeffler AMHonarmand SFlood JMBaxter RJacobson SDiagnostic challenges of central nervous system tuberculosis. Emerg Infect Dis2008;14:14735DOIPubMed
  23. Schuster FLYagi SGavali SMichelson DRaghavan RBlomquist IUnder the radar: Balamuthia amebic encephalitis. Clin Infect Dis.2009;48:87987DOIPubMed
  24. Lynch MLee BAzimi PGentsch JGlaser CGilliam SRotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin Infect Dis2001;33:9328DOIPubMed
  25. Arnold JCSingh KKMilder ESpector SASawyer MHGavali SHuman metapneumovirus associated with central nervous system infection in children. Pediatr Infect Dis J2009;28:105760DOIPubMed
  26. Dalmau JTüzün EWu HYMasjuan JRossi JEVoloschin AParaneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol2007;61:2536DOIPubMed
  27. Gable MSGavali SRadner ATilley DHLee BDyner LAnti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis2009;28:14219DOIPubMed
  28. Armangue TLeypoldt FMálaga IRaspall-Chaure MMarti INichter CHerpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol2014;75:31723 . DOIPubMed
  29. Pahud BAGlaser CADekker CLArvin AMSchmid DSVaricella zoster disease of the central nervous system: epidemiological, clinical, and laboratory features 10 years after the introduction of the varicella vaccine. J Infect Dis2011;203:31623DOIPubMed
  30. Melekhin VVKarem KLDamon IKBloch KCEncephalitis after secondary smallpox vaccination. Clin Infect Dis2009;48:e12DOIPubMed
  31. Pahud BARowhani-Rahbar AGlaser CGavali SSalibay CJFireman BLack of association between childhood immunizations and encephalitis in California, 1998–2008. Vaccine2012;30:24753DOIPubMed
  32. Honarmand SGlaser CAChow ESejvar JJPreas CPCosentino GCSubacute sclerosing panencephalitis in the differential diagnosis of encephalitis. Neurology2004;63:148993DOIPubMed
  33. Rellosa NBloch KCShane ALDebiasi RLNeurologic manifestations of pediatric novel H1N1 influenza infection. Pediatr Infect Dis J.2011;30:1657DOIPubMed
  34. Centers for Disease Control and Prevention. ArboNET. West Nile virus disease cases and deaths reported to CDC by year and clinical presentation, 1999–2013 [cited 2015 Feb 10].http://www.cdc.gov/westnile/resources/pdfs/cummulative/99_2013_CasesAndDeathsClinicalPresentationHumanCases.pdf
  35. Briese TJia XYHuang CGrady LJLipkin WIIdentification of a Kunjin/West Nile-like flavivirus in brains of patients with New York encephalitis.Lancet1999;354:12612DOIPubMed
  36. Francisco AMGlaser CFrykman ECole BCheung MMeyers H2004 California pediatric West Nile virus case series. Pediatr Infect Dis J.2006;25:814DOIPubMed
  37. Jean CMHonarmand SLouie JKGlaser CARisk factors for West Nile virus neuroinvasive disease, California, 2005. Emerg Infect Dis.2007;13:191820DOIPubMed
  38. Ayscue PVan Haren KSheriff HWaubant EWaldron PYagi SCenters for Disease Control and PreventionAcute flaccid paralysis with anterior myelitis—California, June 2012–June 2014. MMWR Morb Mortal Wkly Rep2014;63:9036 .PubMed
  39. Centers for Disease Control and PreventionNotes from the field: acute flaccid myelitis among persons aged ≤21 years—United States, August–November 2014. MMWR Morb Mortal Wkly Rep2015;63:12434 .PubMed
  40. Messacar KSchreiner TLMaloney JAWallace ALudke JOberste MSA cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA. Lancet2015;385:166271DOIPubMed

Tables

Suggested citation for this article: Bloch KC, Glaser CA. Encephalitis surveillance through the Emerging Infections Program, 1997–2010. Emerg Infect Dis. 2015 Sep [date cited]. http://dx.doi.org/10.3201/eid2109.150295
DOI: 10.3201/eid2109.150295

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