domingo, 21 de junio de 2015

Precision Genomic Medicine in Cystic Fibrosis. - PubMed - NCBI

Precision Genomic Medicine in Cystic Fibrosis. - PubMed - NCBI



 2015 Jun 15. doi: 10.1111/cts.12292. [Epub ahead of print]

Precision Genomic Medicine in Cystic Fibrosis.

Abstract

The successful application of precision genomic medicine requires an understanding of how a person's genome can influence his or her disease phenotype and how medical therapies can provide personalized therapy to one's genotype. In this review, we highlight advances in precision genomic medicine in cystic fibrosis (CF), a classic autosomal recessive genetic disorder. We discuss genotype-phenotype correlations in CF, genetic and environmental modifiers of disease, and pharmacogenetic therapies that target specific genetic mutations thereby addressing the primary defect of cystic fibrosis. Clin Trans Sci 2015; Volume #: 1-5.
© 2015 Wiley Periodicals, Inc.

KEYWORDS:

epithelium; genes; genetics

PMID:
 
26073768
 
[PubMed - as supplied by publisher]

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