Venous Thromboembolism: Recent Genomic Insights - June 24, 2015

Genomics|Features|Venous Thromboembolism

Deep Vein Thrombosis/Venous Thromboembolism

Venous Thromboembolism: Recent Genomic Insights - June 24, 2015

CDC and Related Info

• Blood clots and travel: What you need to know
• Deep vein thrombosis/pulmonary embolism are often underdiagnosed and serious, but preventable medical conditions
• Risk factors for DVT/PE include family health history and inherited thrombophillias
• Blood clots and long-distance travel: Advising patients,
• Genes reported in relation to deep vein thrombosis/pulmonary embolism, including genomewide association studies via theHuGE Navigator

CDC information: Blood clots and travel: What you need to know

JAMA Patient Page: Deep Vein Thrombosis
Thompson AE , JAMAMay 26, 2015

Venous thrombosis
Wolberg A et al. Nature Reviews Disease Primers May 2015

CDC information: March is Deep Vein Thrombosis Awareness Month Are you at risk?

Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism.
Lewis Deborah A et al. Thromb. Res. 2015 Feb 7.

Prevalence of hereditary thrombophilia in patients older than 75 years with venous thromboembolism referred for thrombophilia screening.
Siguret Virginie et al. J. Gerontol. A Biol. Sci. Med. Sci. 2015 Feb 9.

Economic analysis of Thrombo inCode, a clinical-genetic function for assessing the risk of venous thromboembolism.
Rubio-Terrés C et al. Appl Health Econ Health Policy. 2015 Feb 5.

Venous thromboembolism in heart transplantation: Should we consider genetic predisposition?
Dolapoglu Ahmet et al. J. Heart Lung Transplant. 2014 Dec 18.

Single nucleotide polymorphisms in interleukin-6 and their association with venous thromboembolism.
Yadav Umesh et al. Mol Med Rep 2015 Jan 26.

Polymorphisms in thrombophilic genes are associated with deep venous thromboembolism in an Iranian population.
Farajzadeh Malak et al. Meta Gene 2014 Dec 505-13

Factor V Leiden mutation and high FVIII are associated with an increased risk of VTE in women with breast cancer during adjuvant tamoxifen - Results from a prospective, single center, case control study.
Kovac Mirjana et al. Eur. J. Intern. Med. 2015 Jan (1) 63-7

Impact of thrombophilic genes mutations on thrombosis risk in Egyptian nonmetastatic cancer patients.
Wahba Mona Ahmed et al. Blood Coagul. Fibrinolysis 2015 Jan 6.

Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors.
Bruzelius M et al. J. Thromb. Haemost. 2015 Feb (2) 219-27

Genetics in thrombophilia. An update.
Reitsma P H et al. Hamostaseologie 2015 Feb 10. (1) 47-51

Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and risk of venous thromboembolism: a meta-analysis.
Wang Jiarong et al. Thromb. Res. 2014 Dec (6) 1241-8

Factor V Leiden mutation increases the risk for venous thromboembolism in cancer patients - results from the Vienna Cancer And Thrombosis Study (CATS).
Pabinger I et al. J. Thromb. Haemost. 2015 Jan (1) 17-22

Venous Thromboembolism: Genetics & Public Health - October 16, 2014

October 13 was World Thrombosis Day:  Reduce your risk by knowing the facts.

CDC information: Deep vein thrombosis/pulmonary embolism are often underdiagnosed and serious, but preventable medical conditions

CDC information: Risk factors for DVT/PE include family health history and inherited thrombophillias

CDC podcast: Blood clots and long-distance travel: Advising patients, Lisa Richardson, Dec 16, 2013

CDC tool on DVT

CDC Flickr album: Personal stories of people living with deep vein thrombosis and pulmonary embolism

CDC HuGE Navigator: Find out which genes have been associated with deep vein thrombosis/pulmonary embolism

CDC article: Modeling uncertain outcomes of genetic testing: Factor V Leiden and pregnant women. 
Grosse SD, Caughey AB Genet Med. 2013 May;15(5):335-7

CDC article: Family history of myocardial infarction is a risk factor for venous thromboembolism among whites but not among blacks. 
Mili FD, Hooper WC, Lally C, Austin H. Clin Appl Thromb Hemost; June 12, 2012.

Genetics of venous thromboembolism, by Svati H Shah and Bruce Buehler, Medscape 2012

Association of venous thromboembolism with hormonal contraception and thrombophilic genotypes.
Bergendal A, et al. Obstet Gynecol. 2014 Sep;124(3):600-9.

Venous thromboembolism and varicose veins share familial susceptibility: a nationwide family study in Sweden.
Zöller B, et al. J Am Heart Assoc. 2014 Aug 26;3(4). pii: e000850.