Mismatch Repair Deficiency & Immune Therapy: Recent Insights - June 1, 2015

Genomics|Features|Lynch Syndrome

Lynch Syndrome

Mismatch Repair Deficiency & Immune Therapy: Recent Insights - June 1, 2015

CDC Info

• Genetic Testing for Hereditary Colorectal Cancer
• Screen for Life: National Colorectal Cancer Action Campaign
• Colorectal Cancer Awareness
• Listen to a CDC podcast about Genetic Testing for Lynch syndrome

PD-1 blockade in tumors with mismatch-repair deficiency
Le DT , et al. NEJM, May 29, 2015

Together, genetic test and drug unleash immune system against tumors, by Matt Herper, Forbes News, May 29

ASCO studies highlight promising biomarkers for predicting response in CRC, lung cancer patients, by Turna Ray, Genomeweb Daily, May 30 [by paid subscription only]

ASCO 2015: Mismatch repair deficiency predicts response to pembrolizumab among patients with colorectal and other cancers, ASCO Post, May 29, 2015

Microsatellite instability: an update.
Yamamoto Hi et al. Arch. Toxicol. 2015 Jun (6) 899-921

Mismatch repair gone awry: management of Lynch syndrome.
Zhang T et al. Crit. Rev. Oncol. Hematol. 2015 Mar (3) 170-9

Lynch Syndrome: Insights into Diagnosis and Screening - May 13, 2015

Next-generation sequencing panels for the diagnosis of colorectal cancer and polyposis syndromes: A cost-effectiveness analysis
Gallego CJ, et al. J Clin Oncology, May 12, 2015

Next-generation sequencing panels cost-effective for diagnosis of hereditary colorectal cancer, Cancer Therapy Advisor, May 12

Scanxiety with Lynch syndrome, by Georgia Hurst, Cure Today, Apr 27

A model-based assessment of the cost-utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients.
Snowsill T et al. BMC Cancer 2015 Apr 25. (1) 313

Stakeholder perspectives on implementing a universal Lynch syndrome screening program: a qualitative study of early barriers and facilitators.
Schneider JL et al. Genet. Med. 2015 Apr 16.

Variation in Lynch syndrome.
Church J et al. Dis. Colon Rectum 2015 May (5) e77

One size may not fit all: The debate of universal tumor testing for Lynch syndrome.
Lu KH et al. Gynecol. Oncol. 2015 Apr (1) 2-3

Decisions about prophylactic gynecologic surgery: a qualitative study of the experience of female Lynch syndrome mutation carriers.
Etchegary H et al. Hered Cancer Clin Pract 2015 (1) 10

Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer.
Kallenberg FG et al. Fam. Cancer 2015 Mar 24.

Risk-reducing surgery in hereditary gynecological cancer: Clinical applications in Lynch syndrome and hereditary breast and ovarian cancer.
Adachi M et al. Mol Clin Oncol 2015 Mar (2) 267-273

Family matters in Lynch syndrome.
Kastrinos F et al. J. Natl. Cancer Inst. 2015 Apr (4)

Lynch Syndrome Awareness - April 6, 2015

Lynch syndrome: Five unanswered questions.
Castellsagué Ester et al. Clin. Genet. 2015 Mar 2.

Sharing hope from cancer experience, by Sheldon Birnie, Winnipeg Free Press, Mar 13

A modified Lynch syndrome screening algorithm in colon cancer: BRAF immunohistochemistry is efficacious and cost beneficial.
Roth Rachel M et al. Am. J. Clin. Pathol. 2015 Mar (3) 336-43

Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers.
Kobayashi Yusuke et al. Int. J. Gynecol. Cancer 2015 Mar (3) 440-6

Improving the uptake of predictive testing and colorectal screening in Lynch syndrome: a regional primary care survey.
Barrow P et al. Clin. Genet. 2015 Feb 4.

Milestones of Lynch syndrome: 1895-2015.
Lynch Henry T et al. Nat. Rev. Cancer 2015 Feb 12.

Lynch syndrome: The basics, by Dennis Ahnen, Fight Colorectal Cancer Blog Post, Jan 15

Economic evaluation of genetic screening for Lynch syndrome in Germany. 
Franziska Severin, et al. Genetics in Medicine, January 8, 2015

Barriers and motivators for referral of patients with suspected Lynch syndrome to cancer genetic services: A qualitative study
Tan YY & Fitzgerald LJ J Pers Med 2014;4(1):20-34

Next-generation strategies for hereditary colorectal cancer risk assessment. 
Yurgelun MB J Clin Oncol. 2015 Jan 5. pii: JCO.2014.58.9895.

Screening for Lynch syndrome: It is time to shift the focus
Kidambi TD & Terdiman JP Dig Dis Sci 2015 Jan

Cost-effectiveness and diagnostic effectiveness analyses of multiple algorithms for the diagnosis of Lynch syndrome.  
Gould-Suarez M, et al. Dig Dis Sci 2014 Dec;59(12)2913-26.

Comparative effectiveness of screening strategies for Lynch syndrome.
Barzi A et al. J. Natl. Cancer Inst. 2015 Apr 107(4)

Lynch Syndrome: Recent Insights - November 6, 2014

Applying public health screening criteria: How does universal newborn screening compare to universal tumor screening for Lynch syndrome in adults with colorectal cancer?
Cragun D, et al. J Genet Couns. 2014 Oct 18

Is it all Lynch syndrome?: An assessment of family history in individuals with mismatch repair–deficient tumors. 
Katherine M. Dempsey et al. Genetics in Medicine, October 23, 2014  

Long-term psychosocial and behavioral adjustment in individuals receiving genetic test results in Lynch syndrome. 
Esplen M, et al. Clin Genet. 2014 Oct 9.

Colonoscopy in patients with Lynch syndrome: no room for error.
Kravochuck SE, Church JM. ANZ J Surg. 2014 Oct 29

Identifying Persons with Lynch Syndrome: Why and How?
Ladabaum U. Dig Dis Sci. 2014 Oct 26.

The impact of risk-reducing gynaecological surgery in premenopausal women at high risk of endometrial and ovarian cancer due to Lynch syndrome.
Moldovan R, Keating S, Clancy T. Fam Cancer. 2014 Oct 24.

Long-term psychosocial and behavioral adjustment in individuals receiving genetic test results in Lynch syndrome.
Esplen MJ, et al. Clin Genet. 2014 Oct 9.

Lynch Syndrome: Awareness and Implementation - September 25, 2014

CDC information: Genetic testing for hereditary colorectal cancer

CDC public health genomics implementation tool kit for health departments- check out Lynch syndrome section

Genetic testing of tumor is recommended for colorectal cancer patients, Science Daily Aug 5

Guidelines on genetic evaluation and management of Lynch syndrome: A consensus statement by the US Multi-Society Task Force on Colorectal Cancer. 
Giardiello FM et al. Dis Colon Rectum. 2014 Aug;57(8):1025-48

NCCN updates guidelines for hereditary colon cancer testing, (March, 2014)

CDC podcast: Genetic testing for Lynch Syndrome in colorectal cancer

Colonoscopy screening compliance and outcomes in patients with Lynch Syndrome. 
Newton K et al.  Colorectal Dis. 2014 Sep 11

Lynch Syndrome - GeneReviews® - NCBI Bookshelf by W Kohlmann et al. (2012)

Lynch syndrome: a pediatric perspective.
SC Huang  et al. J Pediatr Gastroenterol Nutr. 2014

Lynch Syndrome Screening Network- Vision is to reduce the cancer burden associated with Lynch syndrome

Lynch Syndrome International: Mission is to provide support for individuals afflicted with Lynch syndrome, create public awareness of the syndrome, and educate the general public and health care professionals