Liver Cancer: Public Health and Genomic Insights - June 10, 2015

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Liver Cancer

Liver Cancer: Public Health and Genomic Insights - June 10, 2015

Advances in targeted therapies for hepatocellular carcinoma in the genomic era.
Llovet JM et al. Nat Rev Clin Oncol 2015 Jun 9.

Prevention of hepatocellular carcinoma by correction of metabolic abnormalities: Role of statins and metformin.
Ampuero J et al. World J Hepatol 2015 May 18. (8) 1105-11

Hepatocellular carcinoma: From diagnosis to treatment.
Waghray A et al. World J Hepatol 2015 May 18. (8) 1020-9

Relationship between obesity, gut microbiome and hepatocellular carcinoma development.
Hara E et al. Dig Dis 2015 (3) 346-50

PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease.
Salameh H et al. Am. J. Gastroenterol. 2015 Jun (6) 846-56

Genetics of liver disease: From pathophysiology to clinical practice.
Karlsen TH et al. J. Hepatol. 2015 Apr (1S) S6-S14

Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma.
Wang Zhi-C et al. Tumour Biol. 2015 Apr 12.

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
Schulze K et al. Nat. Genet. 2015 May (5) 505-11

Liver Cancer: Recent Insights from Genomics - December 30, 2014

Nature Outlook Special Supplement (December, 2014): Liver cancer is one of the most lethal forms of the disease. If researchers can understand why some people with unhealthy livers develop cancer but others do not, they may be able to treat and prevent the disease more effectively 

A preventable cancer. 
Lucas Laursen. Nature 516, S2-S3 (04 December 2014)

Microbiome: The bacterial tightrope
Katherine Bourzac. Nature 516, S14-S16 (04 December 2014)

Sex differences: Luck of the chromosomes
Courtney Humphries. Nature 516, S10-S11 (04 December 2014)

Exploration of liver cancer genomes
Tatsuhiro Shibata et al. Nature Reviews Gastroenterology & Hepatology 11, 340–349 (28 January 2014)

Liver Cancer: Hepatitis and Genetics - October 2, 2014

CDC information: Viral hepatitis is the leading cause of liver cancer and the most common reason for liver transplantation. An estimated 4.4 million Americans are living with chronic hepatitis; most do not know they are infected

CDC information: Getting tested for Hepatitis B can prevent serious liver damage via life saving treatment

Liver cancer information from the National Cancer Institute

Risk factors for liver cancer include hepatitis and genetics, from the American Cancer Society  

Did you know? 396 genes have been reported in relation to risk and outcomes of liver cancer, including 13 genomewide association studies. To find out more, visit the HuGE Navigator