Cancer Precision Medicine: Improving Evidence in Practice - June 4, 2015

Genomics|Features|Cancer Precision Medicine

Cancer Precision Medicine

Cancer Precision Medicine: Improving Evidence in Practice - June 4, 2015

Use of whole genome sequencing for diagnosis and discovery in the cancer genetics clinic.
Foley SB et al. EBioMedicine 2015 Jan 2(1) 74-81

The future of molecular medicine: biomarkers, BATTLEs, and big data 
ES Kim, ASCO University, June 2015

NCI-MATCH trial will link targeted cancer drugs to gene abnormalities

Targeted agent and profiling utilization registry study, from the American Society for Clinical Oncology

ASCO study aims to learn from patient access to targeted cancer drugs used off-label, American Society for Clinical Oncology

Improving evidence developed from population-level experience with targeted agents  [PDF 462.93 KB]
McLellan M et al Issue Brief. Conference on Clinical Cancer Research November 2014

Implementing personalized cancer care.
Schilsky RL et al. Nat Rev Clin Oncol 2014 Jul (7) 432-8

Accelerating the delivery of patient-centered, high-quality cancer care.
Abrahams E et al. Clin. Cancer Res. 2015 May 15. (10) 2263-7

Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity.
Catenacci DV et al. Mol Oncol 2015 May (5) 967-996

Precision Medicine: Cancer and Genomics - May 12, 2015

Promise, peril seen in personalized cancer therapy, by Marie McCullough, Philadelphia Inquirer, May 10

A decision support framework for genomically informed investigational cancer therapy.
Meric-Bernstam F et al. J. Natl. Cancer Inst. 2015 Jul (7)

Divide and conquer: The molecular diagnosis of cancer, by Louis M. Staudt, National Cancer Insitute, Apr 13

Health: Make precision medicine work for cancer care
To get targeted treatments to more cancer patients pair genomic data with clinical data, and make the information widely accessible, Mark A. Rubin. Nature News, Apr 15

Using somatic mutations to guide treatment decisions
Horlings H et al. JAMA Oncology, March 12, 2015

The landscape of precision cancer medicine clinical trials in the United States
Roper N et al. Cancer Treatment Reviews 2015

What is “precision medicine? Information from the National Cancer Institute

Impact of cancer genomics on precision medicine for the treatment of cancer, from the Cancer Genome Atlas, NCI

US precision-medicine proposal sparks questions, by Sara Reardon, Nature News, Jan 22

Obama's 'precision medicine' means gene mapping, NBC News, Jan 21

What is President Obama's 'precision medicine' plan, and how might it help you? By Lenny Bernstein, Jan 21

Recent reviews

Companion diagnostics: the key to personalized medicine.
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6

Promoting precision cancer medicine through a community-driven knowledgebase.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.

Toward a prostate cancer precision medicine.
Rubin MA. Urol Oncol. 2014 Nov 20.

Prioritizing targets for precision cancer medicine.
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303

Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.

Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer.
Pinto N, et al.  J Oncol. 2014;936285

Translating genomics for precision cancer medicine.
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415

Cancer Precision Medicine: Where Are We? - September 18, 2014

NIH announces the launch of 3 integrated precision medicine trials; ALCHEMIST is for patients with certain types of early-stage lung cancer, August 2014 

National Cancer Institute's Precision Medicine Initiatives for the New National Clinical Trials Network.Jeffrey Abrams et al. ASCO Annual Meeting 2014 

Personalized medicine: Special treatment. 
Michael Eisenstein. Nature, September 11, 2014

Why the controversy? Start sequencing tumor genes at diagnosis. Tumor sequencing at the time of diagnosis can give significant insight for successful cancer treatment, by Shelly Gunn, Genetic Engineering & Biotechnology News, Sep 10  

National Cancer Institute information: Precision medicine and targeted therapy

Genomics and precision oncology: What's a targeted therapy for cancer? An updated list of approved drugs from the National Cancer Institute (2014)

Therapy: This time it's personal
Gravitz L Nature 509, S52-S54 2014 May 29

Multi-marker solid tumor panels using next-generation sequencing to direct molecularly targeted therapies 
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27

Impact of cancer genomics on precision medicine for the treatment of cancer, from the National Cancer Institute

Cancer genomics and precision medicine in the 21st century  [PDF 2.20 MB], power point presentation from the National Human Genome Research Institute