Genomics|Features|Stahylococcus

Genomics|Features|Stahylococcus

Staphylococcus Aureus

Methicillin-Resistant Staphylococcus Aureus: Genomic Insights - February 9, 2015

CDC information: Methicillin-resistant Staphylococcus aureus (MRSA) is a bacteria that is resistant to many antibiotics. In the community, most MRSA infections are skin infections. In medical facilities, MRSA causes life-threatening bloodstream infections, pneumonia and surgical site infections.

Duke, UConn researchers use protein design algorithms to predict potential resistance mutations in MRSA, by Thomas UG, GenomeWeb, Jan 8 [by paid subscription only]

Superbugs meet their match in rapid genome sequencing. Close to real-time tracking of deadly superbugs such as MRSA promises to close down outbreaks faster and save lives, by Ian Sample, the Guardian, Sep 12, 2014

Hospital-associated MRSA and antibiotic resistance-what have we learned from genomics?
Lindsay JA. Int J Med Microbiol. 2013 Aug;303(6-7):318-23

Promising antibiotic discovered in microbial ‘dark matter’. Potential drug kills pathogens such as MRSA — and was discovered by mining 'unculturable' bacteria, Heidi Ledford, Nature News, Jan 7

Predicting the virulence of MRSA from its genome sequence 
Laabei M, et al. Genome Res, 9 Apr 2014.

MRSA genome predicts toxicity, Bioscience Technology, Apr 9, 2014

Comparative whole genome sequencing of community-associated methicillin-resistant staphylococcus aureus sequence type 8 from primary care clinics in a Texas community. 
Lee GC et al., Pharmacotherapy. 2015 Feb 3. 

Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.
Jones MB, et al. BMC Genomics. 2014 Dec 19;15(1):1145

Metabolic pathway analysis approach: Identification of novel therapeutic target against methicillin resistant Staphylococcus aureus.
Uddin R, et al. Gene. 2015 Feb 10;556(2):213-26.

The genome sequence of a type ST239 methicillin-resistant staphylococcus aureus isolate from a Malaysian hospital.
Lee L, et al. Stand Genomic Sci. 2014 Apr 20;9(3):933-9.

Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus.
Stegger M, et al. MBio. 2014 Aug 26;5(5):e01044-14

Comparative genomics of methicillin-resistant Staphylococcus aureus ST239: distinct geographical variants in Beijing and Hong Kong.
Wang Z, et al. BMC Genomics. 2014 Jun 26;15:529.

Transferable vancomycin resistance in a community-associated MRSA lineage.
Rossi F, et al. N Engl J Med. 2014 Apr 17;370(16):1524-31.