miércoles, 1 de marzo de 2017

There is something rotten in these United States… | MercatorNet

There is something rotten in these United States…



There is something rotten in these United States…



There is something rotten in these United States…

...an ignored, unremarked underclass.
Marcus Roberts | Mar 1 2017 | comment 



Over the past 18 months we have brought various pieces of grim news about the United States’ population health. We looked at the rise in the mortality rate of middle-class whites, the rise in the American suicide rate, and the downturn in the United States’ life expectancy in 2015. My concern that there was an American underclass that was not getting much coverage in most media outlets was strengthened by the unpredicted Trump victory. But I was not aware how bad things are outside the “bubble” until I recently read this piece by demographer Nicholas Eberstadt. It’s entitled “Our Miserable 21st Century” and it certainly makes a powerful argument that, for many Americans, life is not getting better. In fact, the first 16 years of this century have seen their lives get worse.
The piece is quite long, and I’d recommend that you go and read it for yourself, but I’d like to pull out some of the more disturbing aspects of the United States that emerge.
  1. The wealth creation of the USA is growing. In fact, since 2000 the estimated net worth of American households and non-profit institutions has more than doubled to $90 trillion.
  2. However, in terms of GDP, the value added to the US economy since 2007 was only 12 per cent higher. In terms of per capita GDP, the American economy was only 4 per cent higher than it was in late 2007 (prior to the crash) leading Eberstadt to claim that the United States has “suffered something close to a lost decade”.
  3. The number of workers in the USA has declined dramatically since 2000. The Bureau of Labor Statistics estimates that the jobs-to-population ratio for adult civilian men and women has plunged by nearly five per cent (to 59.7 per cent) in the years 2000-2016.
  4. The American work rates have never recovered from the recession of 2001, let alone the crash of 2008. Although the official unemployment rate is only 4.8 per cent, this only counts those still in the labour market and looking for work. It does not count those who are workforce dropouts. Thus, for every unemployed American man aged 25-55 years old, there are another three who are neither working nor looking for work.
  5. Apparently, the recovery since 2008 is the first in US history where the basic labour-market indicator has failed to respond.
  6. It is not only men who have dropped out of the workforce, current work rates for prime-age (25-54 years old) women are now back at the same rates that they were a generation ago, in the late 1980s.
  7. Thus, the 21st century USA economy has produced much more wealth and far less work. Between 2000-2015 the number of paid hours of work per adult civilian dropped by 12 percent!
  8. Aside from the economy, the health conditions of many Americans have declined since 2000. Many of Eberstadt’s statistics we talked about last year, but some further shocking facts include that nearly half of all prime working-age male labour-force dropouts (about 7 million men) currently take pain medication on a daily basis.
  9. These prime working-age male labour-force dropouts (Michael Cook wrote a brilliant piece about these “ghost legions” last year) spend on average 2,000 hours in front of a screen and do very little to help civil society (charitable work, religious activities, volunteering etc).
  10. Much of this medication was funded by Medicaid and other federal disability benefits. Over one fifth of all civilian men aged 25 to 55 years old were Medicaid beneficiaries as of 2013 (!), of those of the same age not in the workforce, that share jumped to 53 per cent.
Finally, the great American Dream is perhaps dying. Geographical mobility in America has been on the decline for three decades and American labour market fluidity continues to decline. Thus, the ability for people to get ahead by moving homes and moving jobs has also declined. In short, there seems to be a vast underclass in the United States which has less of a chance of moving up the economic and social ladder than ever before. Troubling stuff… 
Marcus Roberts is the editor of Demography is Destiny, MercatorNet's blog about demography.
- See more at: https://www.mercatornet.com/demography/view/there-is-something-rotten-in-these-united-states/19405#sthash.dmPkL3j9.dpuf





MercatorNet

Can we all just stop talking about Donald Trump for a few minutes? Because if we were all talking about Hillary Clinton instead and Mr Trump had become an historical footnote, America’s problems would remain.

And those are what should worry us, not his spats with journalists. In today’s lead story Marcus Roberts directs readers towards a searing analysis of the crisis of work in the US. Economist Nicholas Eberstadt points out that the unemployment figures are terribly misleading. Economists tell us that the current rate is 4.8%, almost full employment.

But Eberstadt shows that for every unemployed man there are three who are not even looking for work. They just sit around and do not much of anything. As he points out, it is a huge loss of human potential. Read all about it.




Michael Cook 
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There is something rotten in these United States…

Press Announcements > FDA approves Xermelo for carcinoid syndrome diarrhea

Press Announcements > FDA approves Xermelo for carcinoid syndrome diarrhea

u s food and drug administration



02/28/2017 04:30 PM EST


The U.S. Food and Drug Administration today approved Xermelo (telotristat ethyl) tablets in combination with somatostatin analog (SSA) therapy for the treatment of adults with carcinoid syndrome diarrhea that SSA therapy alone has inadequately controlled.

Think You’re Seeing Double? – NLM Musings from the Mezzanine

Think You’re Seeing Double? – NLM Musings from the Mezzanine

National Institutes of Health, U.S. National Library of Medicine



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Rare Disease Mystery: Nodding Syndrome May Be Linked to Parasitic Worm | NIH Director's Blog

Rare Disease Mystery: Nodding Syndrome May Be Linked to Parasitic Worm | NIH Director's Blog

NIH logo: National Institutes of Health, Turning Discovery Into Health

02/28/2017 09:00 AM EST


In the early 1960s, reports began to surface that some children living in remote villages in East Africa were suffering mysterious episodes of “head nodding.” The condition, now named nodding syndrome, is recognized as a rare and devastating form of epilepsy. There were hints that the syndrome might be caused by a parasitic worm called […]


Rare Disease Mystery: Nodding Syndrome May Be Linked to Parasitic Worm

Rural Uganda village gathering
Caption: Village in the East Africa nation of Uganda
Credit: Centers for Disease Control and Prevention
In the early 1960s, reports began to surface that some children living in remote villages in East Africa were suffering mysterious episodes of “head nodding.” The condition, now named nodding syndrome, is recognized as a rare and devastating form of epilepsy. There were hints that the syndrome might be caused by a parasitic worm called Onchocerca volvulus, which is transmitted through the bites of blackflies. But no one had been able to tie the parasitic infection directly to the nodding heads.
Now, NIH researchers and their international colleagues think they’ve found the missing link. The human immune system turns out to be a central player. After analyzing blood and cerebrospinal fluid of kids with nodding syndrome, they detected a particular antibody at unusually high levels [1]. Further studies suggest the immune system ramps up production of that antibody to fight off the parasite. The trouble is those antibodies also react against a protein in healthy brain tissue, apparently leading to progressive cognitive dysfunction, neurological deterioration, head nodding, and potentially life-threatening seizures.
The findings, published in Science Translational Medicine, have important implications for the treatment and prevention of not only nodding syndrome, but perhaps other autoimmune-related forms of epilepsy. As people in the United States and around the globe today observe the 10th anniversary of international Rare Disease Day, this work provides yet another example of how rare disease research can shed light on more common diseases and fundamental aspects of human biology.
Avindra Nath of NIH’s National Institute of Neurological Disorders and Stroke first learned of nodding syndrome at a meeting in Uganda in 2012. In some parts of the country, half of families had a child affected by the condition, leaving many kids in need of constant supervision and medical care. He also heard the condition was a problem in Tanzania and South Sudan.
In search of a cause, Nath was told, scientists had already looked to the immune system, genetics, toxins, nutritional factors, and more. But they still didn’t have an answer. Intrigued, Nath agreed to help.
Nath and his colleagues knew that kids with nodding syndrome often showed signs of onchocerciasis, a devastating skin disease caused by the worm O. volvulus. Onchocerciasis can lead to “river blindness” as the worms migrate into the eyes. But it wasn’t clear how this parasitic infection could affect the brain. Nath, along with his former postdoc Tory Johnson, now at Johns Hopkins School of Medicine, Baltimore, and Thomas Nutman, an onchocerciasis researcher at NIH’s National Institute of Allergy and Infectious Diseases, suspected the problem was autoimmune, a situation in which the body’s defenses accidentally attack its own cells and tissues.
Knowing that earlier attempts to implicate the immune system had come up empty, Johnson decided to take a new approach.  She used more sophisticated protein chip technology. The new approach allowed her to screen for thousands of antibodies at once in pooled samples from kids with nodding syndrome and compare them to those of healthy controls.
Leiomodin-1 inside human neurons
Caption: Leiomodin-1 (green) inside human neurons.
Blue is the nucleus; red indicates the cell membrane.
Credit: Avindra Nath, M.D., National Institute of Neurological
Disorders and Stroke
When Johnson saw the results, one thing immediately jumped out. Antibodies in the blood of youngsters with nodding syndrome reacted 33,000 times more strongly against a protein called leiomodin-1 than in unaffected controls. While the leiomodin-1 antibodies turned up in members of both groups, they seemed to reach much higher levels in many people with nodding syndrome. What’s more, the antibodies were present in cerebrospinal fluid from the central nervous system—so they had somehow crossed the blood-brain barrier.
At the time, Johnson and Nath had never heard of leiomodin-1. A search of the scientific literature indicated the protein was first characterized only about five years ago [2] and is found primarily in muscle and thyroid. But there was no mention of the central nervous system.
The researchers went on to show that leiomodin-1 is actually expressed in mature and developing human neurons. In mouse studies, they also found leiomodin-1 in the very areas of the brain that appear to be affected in humans with nodding syndrome.
As additional evidence, they showed that blood from kids with nodding syndrome containing those leiomodin-1 antibodies could kill neurons in lab dishes. Neurons treated with blood depleted of the leiomodin-1 antibodies survived.
Why would infection with O. volvulus lead to overproduction of neurotoxic leiomodin-1 antibodies? It turns out the worms produce proteins with structural similarities to leiomodin-1. Indeed, the researchers show, leiomodin-1 antibodies also react against several proteins found in the worms’ bodies.
The findings, however, aren’t yet an open-and-shut case. More research is needed to nail down the cause and effect of the infection. But what the evidence does show is once the antibodies attack neurons, the damage is likely permanent. The best way to prevent nodding syndrome is to keep people from becoming infected with O. volvulus in the first place. In fact, efforts to curb the parasitic infection in Uganda with the drug ivermectin (Mectizan®) have already produced a drastic reduction in the incidence of nodding syndrome.
Now that this mystery has been unraveled, it’s tempting to speculate that nodding syndrome may not be the only form of autoimmune-related epilepsy. In fact, in most cases the causes of those conditions still aren’t known. These new findings should encourage researchers to use more powerful technologies and take another hard look at the antibodies and infectious agents—bacteria, viruses, or parasites—that might be responsible for other forms of epilepsy.
References:
[1] Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus. Johnson TP, Tyagi R, Lee PR, Lee MH, Johnson KR, Kowalak J, Elkahloun A, Medynets M, Hategan A, Kubofcik J, Sejvar J, Ratto J, Bunga S, Makumbi I, Aceng JR, Nutman TB, Dowell SF, Nath A. Sci Transl Med. 2017 Feb 15;9(377).
Links:
Nodding Syndrome (Genetic and Rare Diseases Information Center/National Center for Advancing Translational Sciences/NIH)
Nodding Syndrome (World Health Organization)
Onchocerciasis (World Health Organization)
Avindra Nath (National Institute of Neurological Disorders and Stroke/NIH)
Tory Johnson (Johns Hopkins School of Medicine, Baltimore, MD)
Thomas Nutman (National Institute of Allergy and Infectious Diseases/NIH)
NIH Support: National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute