RARE Revolution RARE Bite

https://editions.rarerevolutionmagazine.com/html5/reader/production/default.aspx?pubname=&edid=e0508b93-1cde-4785-b9ae-c36724bde55a&pnum=44 Chronic inflammatory skin diseases like palmoplantar pustulosis (PPP) face a trio of threats—rarity, complexity and, at times, systemic neglect. While they are often grouped under the psoriasis umbrella, PPP is a distinct, debilitating disease with its own pathophysiology, triggers and treatment challenges—and a profound impact on patients’ daily lives. From a healthcare professional’s perspective, PPP faces many challenges: delayed and incorrect diagnosis, disease heterogeneity, a near-absence of robust guidelines, fragmented specialist knowledge and inconsistent access to systemic therapies. This results in underdiagnosis and undertreatment—leaving patients and physicians to navigate not only a diagnostic odyssey but also a therapeutic one.