Researchers suggest a potential therapeutic strategy for muscle loss associated with obesity

https://www.news-medical.net/news/20260804/Researchers-suggest-a-potential-therapeutic-strategy-for-muscle-loss-associated-with-obesity.aspx Obesity has been linked to skeletal muscle loss and deterioration. While M2 macrophages may play a role in regulating muscle function, the underlying mechanisms remain poorly understood. Now, researchers from Japan have found that deleting the signaling protein transforming growth factor-beta 1 from a specific population of M2 macrophages protected mice from obesity-induced muscle dysfunction. This enhanced muscle regeneration and mitochondrial function, suggesting a potential therapeutic strategy for muscle loss associated with obesity.