CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene Expression ++

CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene Expression https://www.azolifesciences.com/news/20260723/CRISPR-Gene-Editing-Reveals-How-Enhancer-Hierarchies-Regulate-Gene-Expression.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_3_august_2026 CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene ExpressionEnhancers are pieces of DNA that act like switches, regulating when genes are turned on and off and how strongly they are activated. Deep-Learning Holography Detects Elusive Circulating Tumor Cells in Prostate Cancer https://www.azolifesciences.com/news/20260727/Deep-Learning-Holography-Detects-Elusive-Circulating-Tumor-Cells-in-Prostate-Cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_3_august_2026 Deep-Learning Holography Detects Elusive Circulating Tumor Cells in Prostate CancerResearchers combined microfluidic enrichment, AI-assisted holography, and fluorescence profiling to identify circulating tumor cell candidates in 13 men with metastatic castration-resistant prostate cancer and 8 healthy donors. The platform found higher median candidate counts in patients, while nearly two-thirds of PSMA-positive candidates lacked EpCAM, suggesting EpCAM-dependent assays could miss some cells.