Nanobody cocktail shows promise as broad-spectrum antivenom A recombinant antivenom made of five nanobodies protected mice against lethal doses of venom from four medically important snake species in India. Written byAndrea Corona

Nanobody cocktail shows promise as broad-spectrum antivenom A recombinant antivenom made of five nanobodies protected mice against lethal doses of venom from four medically important snake species in India. Written byAndrea Corona https://www.drugdiscoverynews.com/nanobody-cocktail-shows-promise-as-broad-spectrum-antivenom-17530 Snakebite envenoming kills between 80,000 and 140,000 people worldwide each year, and India alone accounts for roughly 58,000 of those deaths, disproportionately affecting rural agricultural communities. Current treatment relies on antivenoms made by immunizing horses with venom, a decades-old approach that suffers from batch-to-batch variability, limited coverage of geographically distinct venoms, and risk of severe allergic reactions. In India, commercial antivenoms are formulated against the so-called "big four" snakes and often provide little protection against other clinically important species.