Study uncovers molecular trigger behind pyrin inflammation in familial Mediterranean fever

https://www.news-medical.net/news/20260807/Study-uncovers-molecular-trigger-behind-pyrin-inflammation-in-familial-Mediterranean-fever.aspx Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease in which the body's own immune system overreacts to minimal or inappropriate stimuli, producing recurrent attacks of fever and painful inflammation. The disease is caused by mutations in MEFV, the gene that encodes a protein called pyrin. Inside our cells, pyrin sits at the center of a large protein complex known as an inflammasome, a built-in alarm system that detects bacteria and other dangers and triggers inflammation to protect the body.