sábado, 4 de agosto de 2018

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers | Fluids and Barriers of the CNS | Full Text

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers | Fluids and Barriers of the CNS | Full Text

Fluids and Barriers of the CNS



Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS201815:19
  • Received: 5 March 2018
  • Accepted: 28 May 2018
  • Published: 

Abstract

Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short distances. EVs are thought to be produced by nearly every cell type, however this review will focus specifically on EVs that originate from cells at the interface of CNS barriers. Highlighted topics include, EV biogenesis, the production of EVs in response to neuroinflammation, role in intercellular communication and their utility as a therapeutic platform. In this review, novel concepts regarding the use of EVs as biomarkers for BBB status and as facilitators for immune neuroinvasion are also discussed. Future directions and prospective are covered along with important unanswered questions in the field of CNS endothelial EV biology.

No hay comentarios:

Publicar un comentario