The interplay between the host and HSV-1 infection
Edited by Chunfu Zheng
This article collection, published in Virology Journal, is to help us not only improve our knowledge of virus-host interactions but also develop novel antiviral approaches and vaccines against Herpes simplex virus type 1 (HSV-1) infection. HSV-1 is a typical human-restricted pathogen, which is carried by 50-90% of the population worldwide, with higher frequencies in developing countries. HSV-1 is well known for its ability to establish a lifelong latent infection in neurons and trigger reactivation and lytic infection, mainly in epithelial or mucosal cells.
Although HSV-1 was identified over 100 years ago, the battle between HSV-1 and the host continues, as there is no vaccine yet available, and HSV-1 is still one of the major infectious diseases worldwide.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.
Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...
Authors:Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam
Herpes simplex virus type 1 (HSV1), a member of the alphaherpesvirinae, can cause recurrent facial lesions and encephalitis. Two membrane envelopment processes, one at the inner nuclear membrane and a second a...
Authors:Melanie Ott, Débora Marques, Christina Funk and Susanne M. Bailer
HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins. However, the me...
Authors:Yalan Liu, Mei Li, Di Zhang, Mudan Zhang and Qinxue Hu
One of the most important functions of long noncoding RNAs (lncRNAs) is to control protein coding gene transcription by acting locally in cis, or remotely in trans. Herpes Simplex Virus type I (HSV-1) latently...
Herpes simplex virus 1 (HSV-1) is composed of complex structures primarily characterized by four elements: the nucleus, capsid, tegument and envelope. The tegument is an important viral component mainly distri...
Human herpes simplex virus (HSV) is a ubiquitous human pathogen that establishes a lifelong latent infection and is associated with mucocutaneous lesions. In multicellular organisms, cell death is a crucial ho...
Replication of viral genome is the central event during the lytic infectious cycle of herpes simplex virus 1 (HSV-1). However, the details of HSV-1 replication process are still elusive due to the limitations ...
Authors:Zhuoran Li, Ce Fang, Yuanyuan Su, Hongmei Liu, Fengchao Lang, Xin Li, Guijun Chen, Danfeng Lu and Jumin Zhou
Herpes simplex virus (HSV) is a neurotropic virus that establishes lifelong latent infection in human ganglion sensory neurons. This unique life cycle necessitates an intimate relation between the host defense...
Extracellular vesicles are defined as a heterogeneous group of vesicles that are released by prokaryotic to higher eukaryotic cells and by plant cells in an evolutionary conserved manner. The significance of t...
Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran...
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