Resilience in Dementia

Resilience in Dementia

Resilience in Dementia

Brain resilience is the process of adapting well in the face of significant sources of stress, such as Alzheimer’s disease pathology, other neurodegenerative conditions or biological aging. This thematic series entitled “Resilience in dementia” comprises nine articles covering a wide range of topics, including concepts related to resilience (e.g. brain reserve, cognitive reserve and brain maintenance), its underlying mechanisms (e.g. left frontal cortex functional connectivity) and consequences for disease trajectories (e.g. rates of progression to dementia). The contributions span from perspective papers to strictly data-driven articles and range from cell/animal models, to cognitively normal individuals to clinical populations. Altogether, this thematic series provides a comprehensive overview of what factors contribute to brain resilience and how this affects brain health and cognitive function.

Guest ​​​​​​​Editor: Rik Ossenkoppele

Published: Ongoing

1. Content Type:Research

   Metabolic correlates of reserve and resilience in MCI due to Alzheimer's Disease (AD)

   We explored the presence of both reserve and resilience in late-converter mild cognitive impairment due to Alzheimer’s disease (MCI-AD) and in patients with slowly progressing amyloid-positive MCI by assessing...

   Authors:Matteo Bauckneht, Andrea Chincarini, Roberta Piva, Dario Arnaldi, Nicola Girtler, Federico Massa, Matteo Pardini, Matteo Grazzini, Hulya Efeturk, Marco Pagani, Gianmario Sambuceti, Flavio Nobili and Silvia Morbelli

   Citation:Alzheimer's Research & Therapy 2018 10:35

   Published on: 3 April 2018

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2. Content Type:Review

   Naming is not explaining: future directions for the “cognitive reserve” and “brain maintenance” theories

   Contemporary imaging measures of the human brain explain less than half of the differences in cognitive functioning and change among older adults. Researchers have advanced several theories and concepts to gui...

   Authors:Jonna Nilsson and Martin Lövdén

   Citation:Alzheimer's Research & Therapy 2018 10:34

   Published on: 2 April 2018

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3. Content Type:Research

   The left frontal cortex supports reserve in aging by enhancing functional network efficiency

   Recent evidence derived from functional magnetic resonance imaging (fMRI) studies suggests that functional hubs (i.e., highly connected brain regions) are important for mental health. We found recently that gl...

   Authors:Nicolai Franzmeier, Julia Hartmann, Alexander N. W. Taylor, Miguel Á. Araque-Caballero, Lee Simon-Vermot, Lana Kambeitz-Ilankovic, Katharina Bürger, Cihan Catak, Daniel Janowitz, Claudia Müller, Birgit Ertl-Wagner, Robert Stahl, Martin Dichgans, Marco Duering and Michael Ewers

   Citation:Alzheimer's Research & Therapy 2018 10:28

   Published on: 6 March 2018

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