The Analyzing Data using GDC Data Analysis, Visualization, and Exploration (DAVE) Tools workshop will help introduce users to GDC tools for analyzing data from cancer genomic studies. As an example, we will explore most frequently mutated genes and mutations and perform a survival analysis for cases with and without these mutations, view the distribution of particular mutations and mutated genes across the GDC and visualize associated transcripts in a protein viewer, build custom gene sets for targeted analysis, perform integrated analysis on the most mutated cases in an OncoGrid, and analyze cases within and across projects.
The Querying and Downloading Data using the GDC Data Portal and the GDC Data Transfer Tool workshop will help introduce users to the GDC tools for downloading and retrieving data from cancer genomic studies. As an example, we will query and download open access data using the GDC Data Portal and the high performance GDC Data Transfer Tool. We will also review the process for obtaining access to controlled data and demonstrate how to generate a token for downloading controlled access data.
The Navigating the GDC - A Case Study workshop is the first workshop in a series of NCI GDC Workshops. This workshop will help introduce users to the different GDC tools and data types that are available to support cancer genomic analysis. As an example, we will identify common p53 mutations in colon cancer in the GDC cBioPortal, verify mutation calls using BAM slicing in the GDC Data Portal, and investigate the impact of mutations on RNA-Seq expression. In the process we will also highlight the GDC Data Transfer Tool, harmonized clinical data, and the GDC API.
The NCI’s Genomic Data Commons (GDC) was officially launched on June 6th at the 2016 American Society of Clinical Oncology (ASCO) Annual Meeting by Vice President Joe Biden as part of the National Cancer Moonshot Initiative. The GDC is an interactive data sharing platform that enables the access, standardization, analysis, and submission of cancer genomic data in support of precision medicine. Details about the GDC and support for the National Cancer Moonshot Initiative are available in the NCI Press Release on the GDC Launch.
The NCI’s Genomic Data Commons (GDC) project completes Phase 3 activities. In Phase 3, the GDC generates high level data including DNA-Seq derived germline variants and somatic mutations, RNA-Seq and miRNA-Seq derived gene and miRNA quantifications, and SNP Array based copy number segmentations.
The NCI's Genomic Data Commons (GDC) project completes Phase 2 activities. In Phase 2, the GDC provides support for data submission and harmonization to GRCh38, the latest reference genome build (GRCh38).
The Genomic Data Commons project will help researchers around the country assess genetic information from more than 10,000 cancer patients, which could be used to develop more effective treatments, said Robert Grossman, a professor of medicine at the University of Chicago who is directing the project.
The National Cancer Institute is establishing the NCI Genomic Data Commons (GDC) to store, analyze and distribute cancer genomics data generated by NCI and other research organizations. The GDC will provide an interactive system for researchers to access data, with the goal of advancing the molecular diagnosis of cancer and suggest potential therapeutic targets based on genomic information. The GDC is the first step toward the development of a knowledge system for cancer, as originally recommended in a 2011 Institute of Medicine (IOM) report, “Toward Precision Medicine.”
The University of Chicago and the NCI are collaborating to establish the Genomic Data Commons (GDC). The GDC is a first-of-its-kind facility that will be the most comprehensive system to store data from NCI-funded research programs in a single repository, and harmonize them so they’re compatible. The GDC addresses a major issue in cancer research. A wealth of valuable tumor genome data has been collected by NCI-funded projects, but most researchers can’t make use of the material due to sheer size, disparate formats and dispersed storage locations. By bringing the data together in a single place, in a standardized format, the GDC will dramatically increase access to data for cancer researchers. Not only will this speed up the pace of cancer research, it will open new collaborations and serve as the foundation for future cloud-based research and open the door for new biomedical ecosystems such as personalized treatments for cancer.
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
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