Broadly Neutralizing Antibody Treatment May Target Viral Reservoir in Monkeys
NIH-supported scientists find combination therapy suppresses HIV-like virus in primates
After receiving a course of antiretroviral therapy for their HIV-like infection, half of a group of monkeys infused with a broadly neutralizing antibody to HIV paired with an immune stimulatory compound suppressed the virus for over six months without additional treatment, according to NIAID-supported scientists. The therapy may have targeted the viral reservoir—populations of long-lived, latently infected cells that harbor the virus, and from where the virus rebounds when suppressive therapy is discontinued. The new findings may inform strategies that attempt to achieve sustained, drug-free viral remission in people living with HIV. Researchers discussed their results today at a press conference at the 25th Conference on Retroviruses and Opportunistic Infections (CROI) in Boston.