domingo, 4 de febrero de 2018

Risk management adherence following genetic testing for hereditary cancer syndromes: a Singaporean experience. - PubMed - NCBI

Risk management adherence following genetic testing for hereditary cancer syndromes: a Singaporean experience. - PubMed - NCBI



 2018 Jan 24. doi: 10.1007/s10689-018-0071-9. [Epub ahead of print]

Risk management adherence following genetic testing for hereditary cancer syndromes: a Singaporean experience.

Abstract

Assessing adherence behavior among mutation carriers to cancer risk management guidelines is important for both service improvement and cost-effectiveness analyses, but such real-world data is often lacking. The present study aims to report adherence rates among mutation carriers in a recently established cancer genetics program in Singapore. We conducted a medical chart review of mutation carriers who had attended for genetic counseling and gathered data regarding risk management behavior, including cancer surveillance and/or risk-reducing surgery, and cancers subsequently detected. Of the 52 subjects included in the study, the majority were affected prior to genetic testing (78.8%) and had family history suggestive of a germline mutation (88.5%). The overall adherence rate was 96.2%, including 37 (74.0%) fully-adherent and 13 (26.0%) partially-adherent subjects, with five cancers subsequently detected. Among the 28 BRCA1/2 mutation carriers, adherence to breast cancer risk management was also high (89.3%), although uptake of risk-reducing bilateral salpingo-oophorectomy was not as common (60%). Whilst overall adherence in this cohort was high, BRCA1/2 mutation carriers may require targeted interventions to improve ovarian cancer risk management uptake. Additionally, further education among health professionals and the wider community regarding cancer genetics is needed to ensure the early identification of mutation carriers.

KEYWORDS:

Cancer surveillance; Genetic counseling; Hereditary cancer; Risk management; Risk-reducing surgery

PMID:
 
29368260
 
DOI:
 
10.1007/s10689-018-0071-9

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