jueves, 12 de octubre de 2017

Genomic technologies: development and clinical application

Genomic technologies: development and clinical application

Biomed Central

Genomic technologies: development and clinical application

Guest editor: Stephen Kingsmore

Genome Medicine is pleased to present a special issue on Genomic technologies: development and clinical application. It captures the recent advances in a broad range of genomic technologies with potential to aid in understanding, preventing, diagnosing and treating disease.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest editor declares no competing interests.

    Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases

    Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole ...
    Stephanie U. Greer, Lincoln D. Nadauld, Billy T. Lau, Jiamin Chen, Christina Wood-Bouwens, James M. Ford, Calvin J. Kuo and Hanlee P. Ji
    Genome Medicine 2017 9:57
    Published on: 19 June 2017

    Dissecting the human microbiome with single-cell genomics

    Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genom...
    Andrew C. Tolonen and Ramnik J. Xavier
    Genome Medicine 2017 9:56
    Published on: 14 June 2017

    Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

    Genome-wide loss-of-function profiling is widely used for systematic identification of genetic dependencies in cancer cells; however, the poor reproducibility of RNA interference (RNAi) screens has been a majo...
    Alok Jaiswal, Gopal Peddinti, Yevhen Akimov, Krister Wennerberg, Sergey Kuznetsov, Jing Tang and Tero Aittokallio
    Genome Medicine 2017 9:51
    Published on: 1 June 2017

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