Clinical features and preventive therapies of radiation-induced xerostomia in head and neck cancer patient: a literature review

Graziella Chagas JaguarEmail author,
José Divaldo Prado,
Daniel Campanhã and
Fábio Abreu Alves

Applied Cancer Research201737:31

https://doi.org/10.1186/s41241-017-0037-5

Received: 24 March 2017

Accepted: 5 July 2017

Published: 15 August 2017

Abstract

Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficulties with chewing, swallowing and sleep disorders with significant impact on patients’ quality of life. Current treatment approaches of xerostomia are often difficult and bring in many cases no substantial relief for the patient. This paper discusses the clinical features and current knowledge of xerostomia prevention in order to evaluate the real possibilities of reducing the incidence and severity of this complication in HNC patients. Salivary gland cytoprotectants (amifostine), muscarinic agonist stimulation (pilocarpine and bethanechol), salivary gland-sparing radiation technique (intensity-modulated radiotherapy- IMRT), surgical relocation of the submandibular gland, intraoral stent and stem cell transplantation are promising techniques that are discussed in this study.