domingo, 24 de septiembre de 2017

The McGill Interactive Pediatric OncoGenetic Guidelines: An approach to identifying pediatric oncology patients most likely to benefit from a genet... - PubMed - NCBI

The McGill Interactive Pediatric OncoGenetic Guidelines: An approach to identifying pediatric oncology patients most likely to benefit from a genet... - PubMed - NCBI



 2017 Aug;64(8). doi: 10.1002/pbc.26441. Epub 2017 Jan 18.

The McGill Interactive Pediatric OncoGenetic Guidelines: An approach to identifying pediatric oncology patients most likely to benefit from a genetic evaluation.

Abstract

Identifying cancer predisposition syndromes in children with tumors is crucial, yet few clinical guidelines exist to identify children at high risk of having germline mutations. The McGill Interactive Pediatric OncoGenetic Guidelines project aims to create a validated pediatric guideline in the form of a smartphone/tablet application using algorithms to process clinical data and help determine whether to refer a child for genetic assessment. This paper discusses the initial stages of the project, focusing on its overall structure, the methodology underpinning the algorithms, and the upcoming algorithm validation process.

KEYWORDS:

cancer genetics; cancer predisposition syndrome; familial cancer; germline mutation; pediatric

PMID:
 
28097779
 
DOI:
 
10.1002/pbc.26441

[Indexed for MEDLINE]

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