ATSDR - Toxprofile: Toxicological Profile Information Sheet

ATSDR - Toxprofile: Toxicological Profile Information Sheet

Toxicological Profiles

Information About Contaminants Found at Hazardous Waste Sites

A

• Acetone (PB/95/100095/AS)


• Acrolein (Updated) (PB2008-100001)


• Acrylamide (PB2013-107047)


• Acrylonitrile (PB/91/180489/AS)


• Aldrin/Dieldrin (Updated) (PB2003-100134)


• Aluminum (Updated) (PB2009-100001)


• Americium (PB2004-104396)


• Ammonia (Updated) (PBPB2004-107331)


• Antimony (PB/93/110641/AS)


• Arsenic (Updated) (PB2008-100002)


• Asbestos (Updated) (PB/2001/109101)


• Atrazine (PB2004-100001)

 

B

• 1,3-Butadiene (Updated) (PB2013-105789)


• 1-Bromopropane


• 2,3-Benzofuran (PB/93/110666/AS)


• 2-Butanone (PB/93/110708/AS)


• 2-Butoxyethanol and 2-Butoxyethanol Acetate (PB/99/102527/AS)*


• Barium (Updated) (PB2008-100003)


• Benzene (Updated) (PB2008-100004)


• Benzidine (Updated) (PB/2001/109102)


• Beryllium


• Bis(2-chloroethyl) Ether (PB/90/168683/AS)


• Bis(chloromethyl) Ether (PB/90/168691/AS)


• Boron (Updated) (PB2010-100001)


• Bromodichloromethane (PB/90/167461/AS)


• Bromoform & Dibromochloromethane (Updated) (PB2006-100001)


• Bromomethane (PB/93/110682/AS)

 

C

• Cadmium (Updated) (PB2013-105787)


• Carbon Disulfide (PB97-121073)


• Carbon Monoxide (PB2013-105795)


• Carbon Tetrachloride (Updated) (PB2006-100002)


• Cesium (PB2004-104397)


• Chlordane (Updated) (PB/95/100111/AS)


• Chlordecone (PB/95/264354)


• Chlorfenvinphos (PB/98/101116/AS)


• Chlorinated Dibenzo-p-dioxins (CDDs) (Updated) (PB/99/121998)


• Chlorine (PB2010-100002)


• Chlorine Dioxide & Chlorite (PB 2004-107332)


• Chlorobenzene (PB/91/180505/AS)


• Chlorodibenzofurans (CDFs) (PB/95/100129/AS)


• Chloroethane (Updated) (PB/99/121956)


• Chloroform (Updated) (PB/98/101140/AS)


• Chloromethane (Updated) (PB/99/121964)


• Chlorophenols (Updated) (PB/99/166639)


• Chlorpyrifos (PB/98/103088/AS)


• Chromium (PB2013-105788)


• Cobalt (Updated) (PB 2004-10733)


• Copper (Updated) (PB 2004-10733)


• Creosote (Updated) (PB2003-100136)


• Cresols (Updated) (PB2009-100002)


• Cyanide (Updated) (PB2007-100674)

 

D

• 1,1-Dichloroethane (Final)


• 1,1-Dichloroethene (Updated) (PB/95/100152/AS)


• 1,2-Dibromo-3-Chloropropane (PB/93/110906/AS)


• 1,2-Dibromoethane (PB/93/110740/AS)


• 1,2-Dichloroethane (Updated) (PB/2001/109103/AS)


• 1,2-Dichloroethene (Updated) (PB/97/121081/AS)


• 1,2-Dichloropropane (PB/90/182122/AS)


• 1,2-Diphenylhydrazine (Updated) (PB/91/180356/AS)


• 1,3 Dinitrobenzene & 1,3,5 Trinitrobenzene (PB/95/264289/AS)*


• 1,4-Dioxane (PB2013-105794)


• 2,4-Dichlorophenoxyacetic Acid (2,4-D) (Draft for Public Comment)


• 3,3'-Dichlorobenzidine (Updated) (PB/99/121980)


• DDT, DDE, DDD (Updated) (PB2003-100137)


• DEET (N,N-diethyl-meta-toluamide)


• Di(2-ethylhexyl)phthalate (DEHP) (Updated) (PB2003-100138)


• Di-n-butyl Phthalate (Updated) (PB/2001/109104/AS)


• Di-n-octylphthalate (DNOP) (PB/98/101033/AS)*


• Diazinon (Updated) (PB2009-100003)


• Dichlorobenzenes (Updated) (PB2007-100672)


• Dichloropropenes (Updated) (PB2009-100004)


• Dichlorvos (PB/98/101124/AS)


• Diethyl phthalate (PB/95/264214/AS)*


• Diisopropyl Methylphosphonate (DIMP) (PB/99/102535/AS)*


• Dinitrocresols (Updated) (PB/95/264321)


• Dinitrophenols (PB/95/264339)


• Dinitrotoluenes (Updated)


• Disulfoton (PB/95/264347)

 

E

• Endosulfan (Updated) (Final)


• Endrin (Endrin aldehyde) (Updated) (PB/97/121040/AS)


• Ethion (PB/2000/108024)


• Ethylbenzene (PB2010-100004)


• Ethylene Glycol (PB2010-100005)


• Ethylene Oxide (PB/91/180554/AS)

 

F

• Fluorides, Hydrogen Fluoride, and Fluorine (Updated) (PB2004-100002)


• Formaldehyde (PB/99/166654)


• Fuel Oils / Kerosene (PB/95/264222/AS)*

 

G

• Gasoline, Automotive (PB/95/264206/AS)*


• Glutaraldehyde


• Guthion (PB2009-100005)

 

H

• 2-Hexanone (Updated) (PB/93/110773/AS)


• Heptachlor/Heptachlor Epoxide (Updated) (PB2008-100005)


• Hexachlorobenzene (Updated) (Final)


• Hexachlorobutadiene (PB/95/100160/AS)


• Hexachlorocyclohexane (HCH) (Updated) (PB2006-100003)


• Hexachlorocyclopentadiene (HCCPD) (PB/99/166670)


• Hexachloroethane (PB/98/101041/AS)*


• Hexamethylene Diisocyanate (HDI) (PB/99/102543/AS)*


• HMX (Octogen) (PB/98/101058/AS)*


• Hydraulic Fluids (PB/98/101066/AS)*


• Hydrazines (PB/98/101025/AS)*


• Hydrogen Sulfide Carbonyl Sulfide (Updated)


• n-Hexane (PB/99/166688)

 

I

• Iodine (PB2004-104399)


• Ionizing Radiation (PB/99/163388)


• Isophorone (PB/90/180225/AS)

 

J

• Jet Fuels JP-4 and JP-7 (PB/95/264230/AS)*


• JP-5, JP-8, and Jet A (Updated)

 

L

• Lead (Updated) (PB2008-100007)

 

M

• 4,4'-Methylenebis(2-Chloroaniline)(MBOCA) (PB/95/100186/AS)


• 4,4'-Methylenedianiline (PB/99/102568/AS)*


• Malathion (PB2004-100003)


• Manganese (Updated) (PB2013-105793)


• Mercury (Updated) (PB/99/142416)


• Methoxychlor (Updated) (PB2003-100140)


• Methyl Mercaptan (PB/93/110799/AS)


• Methyl Parathion (PB/2001/109105/AS)


• Methyl tert-Butyl Ether (MTBE) (PB/97/121016/AS)


• Methylene Chloride (Updated) (PB/2000/108026)


• Mirex (PB/95/264354)


• Molybdenum (Draft for Public Comment)

 

N

• n-Nitrosodi-n-propylamine (PB/90/180258/AS)


• n-Nitrosodimethylamine (PB/90/182130/AS)


• n-Nitrosodiphenylamine (Updated) (PB/93/182509/AS)


• Naphthalene, 1-Methylnapthalene, 2-Methylnapthalene (Updated) (PB2006-100004)


• Nickel (Updated) (PB2006-100005)


• Nitrate and Nitrite


• Nitrobenzene (PB/91/180398/AS)


• Nitrophenols (PB/93/110823/AS)

 

O

• Otto Fuel II and its Components (PB/95/264248/AS)*

 

P

• Parathion


• Pentachlorophenol (Updated) (PB/2001/109106/AS)


• Perchlorates (Updated) (PB2009-100006)


• Perfluoroalkyls (Draft for Public Comments)


• Phenol (Updated) (PB2009-100007)


• Phosphate Ester Flame Retardants (PB2013-105796)


• Plutonium (Updated) (PB2010-100006)


• Polybrominated Biphenyls (PBBs) (Updated) (PB2004-107334)


• Polybrominated Diphenyl Ethers (PBDEs) (Updated)


• Polychlorinated Biphenyls (PCBs) (Updated) (PB/2000/108027)


• Polycyclic Aromatic Hydrocarbons (PAHs) (Updated) (PB/95/264370)
  Acenaphthene, Acenaphthylene, Anthracene, Benzo(a)anthracene, Benzo(a)pyrene, Benzo(b)fluoranthene, Benzo(g,h,i)perylene, Benzo(k)fluoranthene, Chrysene, Dibenzo(a,h)anthracene, Fluoranthene, Fluorene, Indeno(1,2,3-cd)pyrene, Phenanthrene, Pyrene


• Propylene Glycol (Updated) (PB2009-103929)*


• Pyrethrins and Pyrethroids (PB2004-100004)


• Pyridine (PB/93/110831/AS)

 

R

• Radium (PB/91/180414/AS)


• Radon (PB2013-104879)


• RDX (Cyclonite) (PB2012-105630)*

 

S

• Selenium (Updated) (PB2004-100005)


• Silica (Draft for Public Comment)


• Silver (PB/91/180430/AS)


• Stoddard Solvent (PB/95/264263)*


• Strontium (PB2004-104400)


• Styrene (PB2010-100007)


• Sulfur Dioxide (PB/99/122020)


• Sulfur Mustard (Updated) (PB2004-100006)


• Sulfur Trioxide & Sulfuric Acid (PB99/122038)


• Synthetic Vitreous Fibers (PB2004-107335)

 

T

• 1,1,1-Trichloroethane (Updated) (PB/95/264396)


• 1,1,2,2-Tetrachloroethane (Updated) (PB2009-100008)


• 1,1,2-Trichloroethane (PB/90/196411/AS)


• 1,2,3 Trichloropropane (PB/93/110872/AS)


• 1,3,5 Trinitrobenzene & 1,3 Dinitrobenzene (PB/95/264289/AS)*
  (See 1,3-Dinitrobenzene)


• 2,4,6-Trinitrotoluene (TNT) (PB/95/264297/AS)*


• Tetrachloroethylene (PERC) (Updated) (Draft for Public Comment)


• Tetryl (PB/95/264271/AS)*


• Thallium (PB/93/110856/AS)


• Thorium (PB/91/180448/AS)


• Tin and Compounds (Updated) (PB2006-100006)


• Titanium Tetrachloride (PB/98/101082/AS)*


• Toluene (Updated)


• Toluene Diisocyanate / Methylenediphenyl Diisocyanate (Draft for Public Comment)


• Total Petroleum Hydrocarbons (TPH) (PB/99/163370)


• Toxaphene (Updated) (Final)


• Trichlorobenzenes (Final)


• Trichloroethylene (TCE) (Updated) (Draft for Public Comment)


• Tungsten (PB2006-100007)

 

U

• Uranium (Updated) (PB2013-105792)


• Used Mineral-based Crankcase Oil (PB/98/101074/AS)*

 

V

• Vanadium (PB2013-105790)


• Vinyl Acetate (PB/93/110898/AS)


• Vinyl Chloride (Updated) (PB2007-100671)

 

W

• White Phosphorus (PB/98/101090/AS)*

 

X

• Xylenes (Updated) (PB2008-100008)

 

Z

• Zinc (Updated) (PB2006-100008)

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Tox Profiles Under Consideration

• ACRYLONITRILE
• 2-BUTANONE
• CHLOROBENZENE
• CHLORODIBENZOFURANS
• DINITROPHENOLs
• ENDRIN
• MIREX & CHLORDECONE
• THORIUM
• 1,1,2-TRICHLOROETHANE
• VINYL ACETATE

Tox Profiles In Development

• Bromodichloromethane
• Bromomethane
• 1,1-Dichloroethene
• 1,2-Dichloropropane
• DDT,DDD, DDE
• Glyphosate
• 2-Hexanone
• Lead
• Perfluoroalkyls
• Pyrethrins
• S,S,S-Tributyl Phosphorotrithioate (Tribufos)
• Bis(2-chloroethyl)ether
• Bis(chloromethyl)ether
• 1,2-Diphenylhydrazine
• N-Nitrosodiphenylamine
• N-Nitrosodi-n-propylamine
• Tetrachloroethylene
• Toluene Diisocyanate
• Trichloroethylene
• Chlordane
• 1,2-Dibromo-3-chloropropane
• 1,2-Dichloroethene
• Dintrocresols
• Hexachlorobutadiene
• Isophorone
• MBOCA
• 1,2,3-Trichloropropane

Tox Profiles Released for Public Comment

• Antimony
• 2,4-D
• Molybdenum
• Silica

Tox Profiles Recently Finalized

• 1-Bromopropane
• DEET
• Glutaraldehyde
• Nitrate/Nitrite
• Toluene

Background

By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces "toxicological profiles" for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure. Toxicological profiles are developed from a priority list of 275 substances. ATSDR also prepares toxicological profiles for the Department of Defense (DOD) and the Department of Energy (DOE) on substances related to federal sites.

Toxicological profiles are developed in two stages:

(1) DRAFTS: The toxicological profiles are first produced as drafts. ATSDR announces in the Federal Register the release of these draft profiles for a 90 day public comment period. Request draft toxicological profiles from ATSDR's Division of Toxicology and Human Health Sciences.

(2) FINALS: After the 90 day comment period, ATSDR considers incorporating all comments into the documents. ATSDR finalizes the profiles.

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Federal Register Notices:

• FRN Set 28 Candidates 
• FRN Set 28 Selection  [PDF, 192 KB]
• FRN Set 27 Drafts for Public Comment   [PDF, 196 KB]
• FRN Set 29 Candidates  [PDF, 196 KB]
• FRN for Glutaraldehyde   [PDF, 185 KB]
• FRN for Jet Fuels & 1-Bromopropane  [PDF, 187 KB]

Profile Development:

• Profile Development Guidance  [PDF, 2 MB]
• Profile Development Guidance Exhibits  [PDF, 1 MB]
• Profile Selection Criteria
• Federal Register Notice [PDF, 964 KB]
• Support Document  [PDF, 2.6 MB]

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Additional Resources:

• Public Health Statements (PHS) - The PHS are a series of summaries about hazardous substances taken from Chapter One of their respective ATSDR Toxicological Profiles.
• ATSDR ToxFAQsTM - The ToxFAQsTM are a series of 2-page fact sheets about hazardous substances
• ATSDR ToxGuidesTM - The ATSDR ToxGuidesTM are quick reference guides providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects.