What is sepsis
Pat had a pneumococcus sepsis because he lost his spleen after a car accident as a teenager. He experienced multiple organ failure, followed by critical illness polyneuropathy.
Sepsis is a life-threatening condition that arises when the body's response to an infection damages its own tissues and organs. It can lead to shock, multiple organ failure, and death, especially if it is not recognized early and treated promptly. Sepsis is the leading cause of death from infection around the world, despite advances in modern medicine like vaccines, antibiotics, and acute care. Millions of people around the world die of sepsis every year.
Sepsis has three stages:
Stage 1:A local infection overcomes the body’s local defense mechanisms, and pathogenic germs and the toxins they produce leave the original site of the infection and enter the circulatory system. This leads to a general inflammatory response called SIRS (systemic inflammatory response syndrome).
Stage 2:The function of individual organs starts to deteriorate and may completely fail.
Stage 3:Several organs stop functioning sequentially or simultaneously, and cardio-circulatory failure leads to a sudden drop in blood pressure. Doctors call this septic shock.
What happens when you have a local infection?A local infection causes local inflammation. The blood vessels around the center of infection expand, becoming more permeable, and the supply of blood increases. The blood also circulates more slowly to allow white blood cells (leukocytes) and messenger substances (semiochemicals) to penetrate the vascular walls into the tissues to fight the pathogens. The blood in the micro-vessels surrounding the infection coagulates. This is the body’s natural defense mechanism; it prevents the pathogens from spilling over into the circulatory system. Typical signs of this local inflammation are increased temperature, redness, pain, and swelling around the center of infection.
When a local infection with inflammation turns into sepsis
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