The Genetics of Pediatric Obesity. - PubMed - NCBI

The Genetics of Pediatric Obesity. - PubMed - NCBI

Trends Endocrinol Metab. 2015 Dec;26(12):711-21. doi: 10.1016/j.tem.2015.08.008. Epub 2015 Oct 1.

The Genetics of Pediatric Obesity.

Chesi A1, Grant SF2.

Author information

Abstract

Obesity among children and adults has notably escalated over recent decades and represents a global major health problem. We now know that both genetic and environmental factors contribute to its complex etiology. Genome-wide association studies (GWAS) have revealed compelling genetic signals influencing obesity risk in adults. Recent reports for childhood obesity revealed that many adult loci also play a role in the pediatric setting. Childhood GWAS have uncovered novel loci below the detection range in adult studies, suggesting that obesity genes may be more easily uncovered in the pediatric setting. Shedding light on the genetic architecture of childhood obesity will facilitate the prevention and treatment of pediatric cases, and will have fundamental implications for diseases that present later in life.

Copyright © 2015 Elsevier Ltd. All rights reserved.

PMID:

 

26439977

 

PMCID:

 

PMC4673034

 [Available on 2016-12-01]

 

DOI:

 

10.1016/j.tem.2015.08.008

[PubMed - in process]

Public Health Genomics Knowledge Base (v1.2)

CHILDHOOD OBESITY

Last Updated: Sep 08, 2016

• The Genetics of Pediatric Obesity.
  Chesi Alessandra et al. Trends in endocrinology and metabolism: TEM 2015 Dec 26(12) 711-21
• The Impact of Familial Predisposition to Obesity and Cardiovascular Disease on Childhood Obesity.
  Nielsen Louise Aas et al. Obesity facts 2015 8(5) 319-28
• Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths.
  Morandi Anita, et al. The Journal of clinical endocrinology and metabolism 2016 9 jc20162432
• Nucleotide variation of sFRP5 gene is not associated with obesity in children and adolescents.
  Van Camp Jasmijn K, et al. Molecular biology reports 2016 8
• Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children.
  Abadi Arkan, et al. Obesity (Silver Spring, Md.) 2016 8
• Exome sequencing in Thai patients with familial obesity.
  Kaewsutthi S, et al. Genetics and molecular research : GMR 2016 0 (2)
• Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children.
  Muñoz-Yáñez C, et al. Genetics and molecular biology 2016 7 0
• Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus.
  Yiallouros Panayiotis K, et al. Italian journal of pediatrics 2016 0 (1) 67
• Genetic markers of inflammation may not contribute to metabolic traits in Mexican children.
  Vashi Neeti, et al. PeerJ 2016 0 e2090
• Long-term Outcomes of Childhood Onset Nephrotic Syndrome.
  Hjorten Rebecca, et al. Frontiers in pediatrics 2016 0 53
• Childhood Predictors of Adult Fatty Liver. The Cardiovascular Risk in Young Finns Study.
  Suomela Emmi, et al. Journal of hepatology 2016 5
• FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population.
  Duicu Carmen, et al. Medicine 2016 5 (20) e3709
• The effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirements in a pediatric population.
  Dilge Ta?k?n Birce, et al. Anatolian journal of cardiology 2016 1
• The effects of Advanced Glycation End Products (RAGE)-374T/A and Gly82Ser variants and soluble-RAGE levels to obesity in children.
  Kucukhuseyin O, et al. Cellular and molecular biology (Noisy-le-Grand, France) 2016 0 (5) 9-14
• APOA5 and APOA1 polymorphisms are associated with triglyceride levels in Mexican children.
  Suárez-Sánchez F, et al. Pediatric obesity 2016 5

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• Cancer Genomics and Epidemiology Navigator (CGEN)
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