Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis: Genomic Insights - February 23, 2015

CDC Info

SnapShot: Genetics of ALS and FTD.

Guerreiro Rita et al. Cell2015 Feb 12. (4) 798-798.e1

The distinct genetic pattern of ALS in Turkey and novel mutations.

Özoguz Aslihan et al.Neurobiol. Aging 2015 Jan 10.

Therapeutic development in amyotrophic lateral sclerosis.

Bucchia Monica et al. Clin Ther 2015 Feb 6.

MicroRNAs: Newcomers into the ALS Picture.

Volonté C et al. CNS Neurol Disord Drug Targets 2015 Jan 16.

Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis.

Morgan Sarah et al. Neurobiol. Aging 2014 Dec 20.

Genetic analysis of amyotrophic lateral sclerosis in the Slovenian population.

Vrabec Katarina et al. Neurobiol. Aging 2014 Dec 18.

Application of next-generation sequencing technologies in neurology.

Jiang Teng et al. Ann Transl Med 2014 Dec (12) 125

Genome-wide association studies in neurology.

Tan Meng-Shan et al. Ann Transl Med 2014 Dec (12) 124

A second-generation Irish genome-wide association study for amyotrophic lateral sclerosis.

McLaughlin Russell L et al. Neurobiol. Aging 2015 Feb (2) 1221.e7-1221.e13

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.

Cady Janet et al. Ann. Neurol. 2015 Jan (1) 100-13

Amyotrophic lateral sclerosis genetic studies: From genome-wide association mapping to genome sequencing.

He Ji et al. Neuroscientist 2014 Nov 5.

Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.

Smith Bradley N et al. Neuron 2014 Oct 22. (2) 324-31

Amyotrophic Lateral Sclerosis: National Registry, Biorepository and Genetics - August 7, 2014

Prevalence of amyotrophic lateral sclerosis — United States, 2010–2011,

[PDF 575.05 KB]Agency for Toxic Substances and Disease Registry, MMWR, July 25, 2014

National Amyotrophic Lateral Sclerosis (ALS) registry from the Agency for Toxic Substances and Disease Registry

What causes ALS? Although no cause has been found for most cases of ALS, a number of inherited factors have been found to cause familial ALS

National ALS Biorepository. Little is known about the role genetics play in ALS. In order to find out more, researchers need biological samples like blood or tissue from persons living with ALS . ATSDR is coordinating a feasibility study to find the best way to collect and store these samples.

Genetics and ALS: Find out more information from the NIH Genetics Home Reference

- An estimated 5 to 10 percent of ALS is familial and caused by mutations in one of several genes

Keeping up with genetic discoveries in amyotrophic lateral sclerosis: ALSGene database

Amyotroph Lateral Scler. 2011 Jul;12(4):238-49.

Search the ALSGene database for latest genes associated with ALS

Did you know there are 194 genes reported in relation to risk and complications of ALS, including 36 genomewide association studies? To find out more, visit the HuGE Navigator