Statin Therapy, Genetics and Heart Disease - March 25, 2015

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Statin Therapy, Genetics and Heart Disease - March 25, 2015

NIH Research Matters: Genetics help predict heart disease risk, statin benefits

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
Mega J et al, Lancet, March 2015

Statins work for those at highest risk of heart attack - study, the Guardian, Mar 3

Dosing guideline for simvastatin and SLCO1B1, Clinical Pharmacogenomics Implementation Consortium 2014 update

Pharmacogenetics and statin treatment: Reality or theory?
Bousoula E et al. Curr Vasc Pharmacol 2015 Jan 30.

Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.
Kim Kyungpil et al. Genome Biol. 2014 (9) 460

No association between CYP3A4*22 and statin effectiveness in reducing the risk for myocardial infarction.
Leusink Maarten et al. Pharmacogenomics 2014 Aug (11) 1471-7

Pharmacogenetics of statin-induced myopathy: A focused review of the clinical translation of pharmacokinetic genetic variants.
Talameh Jasmine A et al. J Pharmacogenomics Pharmacoproteomics 2014 Apr 23. (2)

The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
Ramsey L B et al. Clin. Pharmacol. Ther. 2014 Oct (4) 423-8

Pharmacogenomics, lipid disorders, and treatment options.
Gryn S E et al. Clin. Pharmacol. Ther. 2014 Jul (1) 36-47

Cardiovascular pharmacogenomics: expectations and practical benefits.
Turner R M et al. Clin. Pharmacol. Ther. 2014 Mar (3) 281-93

Genetics and personalized medicine--a role in statin therapy?
Patel Jaideep et al. Curr Atheroscler Rep 2014 Jan (1) 384

Statin myotoxicity: a review of genetic susceptibility factors.
Needham M et al. Neuromuscul. Disord. 2014 Jan (1) 4-15

Genetic testing: Genetic risk and statin preventative therapy.
Bahcall OG et al. Nat. Rev. Genet. 2015 Apr 16(4) 194