Management of Inherited Thrombophilia: Guide for G... [Clin Genet. 2011] - PubMed result

Management of Inherited Thrombophilia: Guide for G... [Clin Genet. 2011] - PubMed result: "Clin Genet. 2011 Jun 27. doi: 10.1111/j.1399-0004.2011.01746.x. [Epub ahead of print]
Management of Inherited Thrombophilia: Guide for Genetics Professionals.
Varga EA, Kujovich JL.
Source

Division of Hematology/Oncology/BMT, Nationwide Children's Hospital Columbus, OH Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH Division of Hematology/Medical Oncology, Oregon Heath and Science University, Portland, OR.

Abstract

Venous thromboembolism (VTE) is a common source or morbidity and mortality in developed countries. Heritable risk factors for VTE (thrombophilias) can be identified in 30-50% of affected patients. Factor V Leiden, prothrombin 20210G>A, and deficiencies of antithrombin, protein C and protein S increase the risk for a first VTE. However, an individual's thrombotic risk is determined by a complex interplay of genetic, acquired and circumstantial risk factors. At least 50% of VTE events in thrombophilic individuals are provoked by predisposing factors such as immobility, surgery, trauma, cancer, hormonal therapy and pregnancy. Non-modifiable such as advancing age and family history also increase thrombotic risk. An evidence based risk factor evaluation is an essential step in VTE prevention. This review will educate genetics professionals about inherited and acquired risk factors for VTE and discuss recommendations for management of asymptomatic individuals with thrombophilia.

© 2011 John Wiley & Sons A/S.

PMID:
21707594
[PubMed - as supplied by publisher]

- Enviado mediante la barra Google"