domingo, 31 de julio de 2011

Atypical Pestivirus in Calves | CDC EID::Volume 17, Number 8–August 2011

full-text ►Atypical Pestivirus in Calves | CDC EID: "EID Journal Home > Volume 17, Number 8–August 2011
Volume 17, Number 8–August 2011
Atypical Pestivirus and Severe Respiratory Disease in Calves, Europe

Nicola Decaro, Comments to Author Maria Stella Lucente, Viviana Mari, Francesco Cirone, Paolo Cordioli, Michele Camero, Rossana Sciarretta, Michele Losurdo, Eleonora Lorusso, and Canio Buonavoglia

Author affiliations: Faculty of Veterinary Medicine of Bari, Valenzano, Bari, Italy (N. Decaro, M.S. Lucente, V. Mari, F. Cirone, M. Camero, R. Sciarretta, M. Losurdo, E. Lorusso, C. Buonavoglia); and Istituto Zooprofilattico Sperimentale di Lombardia ed Emilia Romagna, Brescia, Italy (P. Cordioli)

Suggested citation for this article

In 2010, a HoBi-like pestivirus was isolated from clinically affected calves in Italy. This European virus reproduced a milder form of disease under experimental conditions and was genetically related to previously reported HoBi-like strains. Isolation of this novel virus from a clinical outbreak may have implications for cattle health and prophylactic programs

Genus Pestivirus (family Flaviviridae) includes Bovine viral diarrhea virus type 1 (BVDV-1) and Bovine viral diarrhea virus type 2 (BVDV-2), Classical swine fever virus (CSFV), Border disease virus (BDV), and other pestivirus species detected in wild ruminants (1,2). In 2004, an atypical pestivirus was isolated from a contaminated batch of calf serum originating from Brazil. This virus, named D32/00_HoBi, was proposed as prototype of a new pestivirus species, BVDV-3 (3). Although additional HoBi-like strains have been detected in South America (4), currently, there is a unique report of natural infection in cattle caused by a HoBi-like strain, Th/04_KhonKaen, which was isolated from a bovine serum sample collected during an epidemiologic survey for BVDV in Thailand (5). However, the virus was not associated with any evident clinical signs. Here we report the biologic and genetic characterization of a HoBi-like strain from Europe that was isolated from cattle during an outbreak of respiratory disease in Italy.

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Suggested Citation for this Article

Decaro N, Lucente MS, Mari V, Cirone F, Cordioli P, Camero M, et al. Atypical pestivirus and severe respiratory disease in calves, Europe. Emerg Infect Dis [serial on the Internet]. 2011 Aug [date cited].

DOI: 10.3201/eid1708.101447

Comments to the Authors

Please use the form below to submit correspondence to the authors or contact them at the following address:

Nicola Decaro, Department of Veterinary Public Health, Faculty of Veterinary Medicine of Bari, Strada per Casamassima km 3, 70010 Valenzano, Bari, Italy; email:

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