Is the treatment of CIN 2 always necessary in women under 25?

open here please:Is the treatment of CIN 2 always necessary in women under 25?: "Is the treatment of CIN 2 always necessary in women under 25?

* Ms Bree E. Mcallum, BS
Affiliations
o University of Otago, Christchurch School of Medicine, New Zealand
o Corresponding Author InformationCorrespondence to: Name: Miss Bree McAllum, Address: University of Otago Christchurch, 5/2 Riccarton Ave, Christchurch, 8011, Department: Obstetrics and Gynaecology, Phone: (64) 274498625
email address
* , Peter H.H. Sykes, MD
Affiliations
o University of Otago, Christchurch School of Medicine, New Zealand. Obstetrics and Gynaecology department, Christchurch Women’s Hospital, 5/2 Riccarton Ave Christchurch, New Zealand.
* , Lynn Sadler, MD
Affiliations
o Auckland DHB Women's Health - Maternity/ Pregnancy Care, Auckland City Hospital, 2 Park Road, Grafton, Auckland, New Zealand.
* , Helene M. Macnab, MD
Affiliations
o University of Otago, Christchurch School of Medicine, New Zealand. Obstetrics and Gynaecology department, Christchurch Women’s Hospital, 5/2 Riccarton Ave Christchurch, New Zealand.
* , Bryony J. Simcock, MD
Affiliations
o University of Otago, Christchurch School of Medicine, New Zealand. Obstetrics and Gynaecology department, Christchurch Women’s Hospital, 5/2 Riccarton Ave Christchurch, New Zealand.
* , Adel K. Mekhail, MD
Affiliations
o University of Otago, Dunedin School of Medicine, New Zealand. Obstetrics and Gynaecology department, Dunedin Hospital, 201 Great King Street, Dunedin, New Zealand.

Received 14 January 2011; received in revised form 14 April 2011; accepted 13 June 2011. published online 27 June 2011.
Accepted Manuscript

* Abstract
* PDF

Abstract
Objective

To review the outcome of cervical intraepithelial neoplasia (CIN) 2 in women under 25 managed conservatively.

Study Design

Retrospective review. Women less than 25 years old with biopsy proven CIN2 between 2005 and 2009 were identified. Analysis was performed comparing women who had immediate treatment with those whose treatment was deferred more than 4 months. The primary outcome measure was spontaneous regression of CIN2. Secondary outcomes were treatment rates and loss to follow-up.

Results

Of the 452 women identified, 256 (57%) received immediate treatment, 157 (35%) met the definition for conservative management and for 39 (9%) women subsequent management was unknown. Of the 157 conservatively managed, 98 (62%) showed spontaneous regression, with a median of 8months follow-up. No conservatively managed women progressed to cancer.

Conclusions

Based on the 62% regression rate in this study, routine treatment may not be necessary for all women under the age of 25 with CIN2.

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