Familial thyroid neoplasia: impact of technologica... [Curr Opin Endocrinol Diabetes Obes. 2010] - PubMed result

Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):425-31.

Familial thyroid neoplasia: impact of technological advances on detection and monitoring.
Tran T, Gianoukakis AG.

aDivision of Endocrinology and Metabolism, Harbor-UCLA Medical Center, Torrance bDavid Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Abstract
PURPOSE OF REVIEW: To weigh the clinical impact of new technological insights into heritable thyroid malignancies.

RECENT FINDINGS: Medullary thyroid carcinoma and familial nonmedullary thyroid cancers represent the small minority of thyroid cancers that are inherited. New insights into the genetic alterations and molecular mechanisms implicated in these tumors are serving to refine the clinical tools available for their initial diagnosis as well as subsequent follow-up. In addition to an analysis of rearranged during transfection mutations and calcitonin profiles in medullary thyroid carcinoma, this review includes emphasis on familial nonmedullary thyroid cancer syndromes, including genetic findings in familial papillary thyroid cancer, familial adenomatous polyposis, Cowden syndrome, Carney complex, and Werner syndrome.

SUMMARY: Genetic mutational information is increasingly available on medullary and familial nonmedullary thyroid cancer and their associated syndromes. The clinical significance of this information for affected patients and their families continues to undergo evaluation.

PMID: 20729730 [PubMed - in process]


Familial thyroid neoplasia: impact of technologica... [Curr Opin Endocrinol Diabetes Obes. 2010] - PubMed result