Editorial Human microbiota, an emerging player in chronic obstructive pulmonary disease eBioMedicine +...

Editorial Human microbiota, an emerging player in chronic obstructive pulmonary disease eBioMedicine https://www.thelancet.com/journals/ebiom/issue/vol131nonull/PIIS2352-3964(26)X2007-2

A new normal? The Lancet Planetary Health +...

A new normal? The Lancet Planetary Health https://www.thelancet.com/journals/lanplh/issue/vol10no7/PIIS2542-5196(26)X2007-1

Breaking barriers in brain gene therapy Researchers are developing new delivery technologies to bring gene therapies to the central nervous system safely and precisely. Written byAlejandra Manjarrez, PhD

Breaking barriers in brain gene therapy Researchers are developing new delivery technologies to bring gene therapies to the central nervous system safely and precisely. Written byAlejandra Manjarrez, PhD https://www.drugdiscoverynews.com/breaking-barriers-in-brain-gene-therapy-17537 By correcting, replacing, or silencing disease-causing genes, gene therapies offer the potential to treat disorders at their source rather than simply managing symptoms. Several gene therapies have already reached the clinic for inherited diseases, demonstrating the promise of genetic medicines. Yet, despite a few landmark approvals for central nervous system (CNS) disorders, widespread and precise delivery to the brain remains one of the field’s greatest challenges.

Cracking the Code: Optimizing Outcomes in All Patients With High-Risk HR+/HER2-Negative Early Breast Cancer Authors: Manali Bhave, MD; Shaheenah Dawood, MBBCh, MPH, FACP; Erika Hamilton, MD, FASCO

https://www.medscape.org/viewarticle/cracking-code-optimizing-outcomes-all-patients-high-risk-hr-2026a1000crj?page=1&src=mkmcmr_driv_stan_mscpedu_260920-OUS-HONC-cracking-code-optimizing-outcomes-all-patients-high-risk-hr-2026a1000crj-cta&uac=148436CN

GLP-1 Systematic Review Finds Weight Loss of Up to 24% Evra Taylor

https://www.medscape.com/viewarticle/glp-1-systematic-review-finds-weight-loss-24-2026a1000yvq?ecd=WNL_trdalrt_pos1_ous_260921_etid8713251&uac=148436CN&impID=8713251 GLP-1 receptor agonists are associated with substantial weight loss in adults with overweight or obesity and without diabetes, according to a systematic review. The range of therapeutic options, which includes oral and multiagonist therapies, is expanding.

Cortisol Excess Severity May Help Predict Recurrence and Progression in Adrenocortical Carcinoma ++++

https://www.medscape.com/viewarticle/cortisol-excess-severity-may-help-predict-recurrence-and-2026a1000z3t?src= Higher urinary free cortisol (UFC) levels at diagnosis were associated with an increased risk for tumor recurrence or progression in patients with Cushing syndrome (CS) secondary to adrenocortical carcinoma (ACC), according to a multicenter international cohort study of 101 patients. Both tumor size and UFC levels independently predicted metastatic disease at diagnosis. EMA Backs Three New Options in Lung and Ovarian Cancers Edited by Joyani Das https://www.medscape.com/viewarticle/ema-backs-three-new-options-lung-and-ovarian-cancers-2026a1000z3i?src= At its September 2026 meeting, European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended granting marketing authorization for three oncology medicines: Gevalka (ensartinib, SFL Pharmaceuticals), Lifyorli (relacorilant, Corcept Therapeutics), and Sepalna (senaparib, SFL Pharmaceuticals). The medicines address different stages of two solid tumor types: ALK-positive non-small cell lung cancer (NSCLC) and epithelial ovarian, fallopian tube, or primary peritoneal cancer. If approved by the European Commission, all three agents would be authorized across the EU... Quality of Life Preserved in Older Patients After Curative Treatment for Colorectal Cancer Metastases https://www.medscape.com/viewarticle/quality-life-preserved-older-patients-after-curative-2026a1000yjz?src= Older patients with metastatic colorectal cancer who received curative local surgical or ablative treatment for metastases maintained quality of life (QOL) over 12 months; physical functioning declined temporarily at 3 months but did not reach clinically relevant levels of decline at any timepoint. Digital Health Is Raising Patient Expectations Silvia C. Carpallo https://www.medscape.com/viewarticle/digital-health-raising-patient-expectations-2026a1000z20 Professional forums are increasingly focusing on how digital health can contribute to clinical workflows, from automating administrative tasks and analyzing imaging studies to segmenting patient groups. However, these discussions often overlook the role of patients and how digital health changes their expectations and perceptions of their healthcare needs.

More Women Say They’ve Never Been Screened for Cervical Cancer Lara Salahi

https://www.medscape.com/viewarticle/more-women-say-theyve-never-been-screened-cervical-cancer-2026a1000z1n?src= When Eleonora Teplinsky, MD, learns that a woman in her forties is getting her first Pap smear, she sees a string of lost opportunities: years of missed screenings, leaving potentially precancerous cervical lesions undetected and untreated.