Orphanet Journal of Rare Diseases

https://ojrd.biomedcentral.com/

FDA approves erdafitinib for locally advanced or metastatic urothelial carcinoma

https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-erdafitinib-locally-advanced-or-metastatic-urothelial-carcinoma?utm_medium=email&utm_source=govdelivery On January 19, 2024, the Food and Drug Administration approved erdafitinib (Balversa, Janssen Biotech) for adult patients with locally advanced or metastatic urothelial carcinoma (mUC) with susceptible FGFR3 genetic alterations, as determined by an FDA-approved companion diagnostic test, whose disease has progressed on or after at least one line of prior systemic therapy. Erdafitinib is not recommended for the treatment of patients who are eligible for and have not received prior PD-1 or PD-L1 inhibitor therapy. This approval amends the indication previously granted under accelerated approval for patients with mUC with susceptible FGFR3 or FGFR2 alterations after prior platinum-containing chemotherapy.

How a Simple Urine Test Could Reveal Early-Stage Lung Cancer Christina Szalinski

https://www.medscape.com/viewarticle/how-simple-urine-test-could-reveal-early-stage-lung-cancer-2024a10001ib

Basic Information About Cervical Cancer

Basic Information About Cervical Cancer https://www.cdc.gov/cancer/cervical/basic_info/ Basic Information about HPV and Cancer https://www.cdc.gov/cancer/hpv/basic_info/ What Should I Know About Screening? https://www.cdc.gov/cancer/cervical/basic_info/screening.htm HPV Vaccine https://www.cdc.gov/hpv/parents/vaccine-for-hpv.html Cervical & vaginal cancer screenings https://www.medicare.gov/coverage/cervical-vaginal-cancer-screenings Cindy’s Story: Preventing Cervical Cancer https://www.cdc.gov/cancer/cervical/resources/index.htm

New Findings in Football Players May Aid the Future Diagnosis and Study of Chronic Traumatic Encephalopathy (CTE) Posted on January 18th, 2024 by Dr. Monica M. Bertagnolli

https://directorsblog.nih.gov/2024/01/18/new-findings-in-football-players-may-aid-the-future-diagnosis-and-study-of-chronic-traumatic-encephalopathy-cte/ Repeated hits to the head—whether from boxing, playing American football or experiencing other repetitive head injuries—can increase someone’s risk of developing a serious neurodegenerative condition called chronic traumatic encephalopathy (CTE). Unfortunately, CTE can only be diagnosed definitively after death during an autopsy of the brain, making it a challenging condition to study and treat. The condition is characterized by tau protein building up in the brain and causes a wide range of problems in thinking, understanding, impulse control, and more. Recent NIH-funded research shows that, alarmingly, even young, amateur players of contact and collision sports can have CTE, underscoring the urgency of finding ways to understand, diagnose, and treat CTE. New findings published in the journal Neurology show that increased presence of certain brain lesions that are visible on MRI scans may be related to other brain changes in former football players. The study describes a new way to capture and analyze the long-term impacts of repeated head injuries, which could have implications for understanding signs of CTE.

National Advisory Eye Council (NAEC) Meeting Agenda 167th Meeting of the National Advisory Eye Council 6700B Rockledge Drive, 1st Floor Conference Room February 16, 2024

https://www.nei.nih.gov/about/advisory-committees/national-advisory-eye-council-naec/national-advisory-eye-council-naec-meeting-agenda-167

The Division of Intramural Research Seminar Series

https://www.nei.nih.gov/events/intramural-research-seminars Scanziani presents intramural seminar Feb. 1 Massimo Scanziani, University of California San Francisco, presents "Orienting eye movements in dreams and wakefulness," as part of the Division of Intramural Research Seminar Series, Thursday, Noon ET, NIH campus, Building 49, Room 1A51/1A52, and via Zoom.